| pubmed-article:18185515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18185515 | lifeskim:mentions | umls-concept:C1442792 | lld:lifeskim |
| pubmed-article:18185515 | lifeskim:mentions | umls-concept:C2612367 | lld:lifeskim |
| pubmed-article:18185515 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:18185515 | pubmed:issue | 7178 | lld:pubmed |
| pubmed-article:18185515 | pubmed:dateCreated | 2008-1-31 | lld:pubmed |
| pubmed-article:18185515 | pubmed:abstractText | There are fundamental similarities between sleep in mammals and quiescence in the arthropod Drosophila melanogaster, suggesting that sleep-like states are evolutionarily ancient. The nematode Caenorhabditis elegans also has a quiescent behavioural state during a period called lethargus, which occurs before each of the four moults. Like sleep, lethargus maintains a constant temporal relationship with the expression of the C. elegans Period homologue LIN-42 (ref. 5). Here we show that quiescence associated with lethargus has the additional sleep-like properties of reversibility, reduced responsiveness and homeostasis. We identify the cGMP-dependent protein kinase (PKG) gene egl-4 as a regulator of sleep-like behaviour, and show that egl-4 functions in sensory neurons to promote the C. elegans sleep-like state. Conserved effects on sleep-like behaviour of homologous genes in C. elegans and Drosophila suggest a common genetic regulation of sleep-like states in arthropods and nematodes. Our results indicate that C. elegans is a suitable model system for the study of sleep regulation. The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes. | lld:pubmed |
| pubmed-article:18185515 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18185515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18185515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18185515 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18185515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18185515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18185515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18185515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18185515 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18185515 | pubmed:issn | 1476-4687 | lld:pubmed |
| pubmed-article:18185515 | pubmed:author | pubmed-author:PackAllan IAI | lld:pubmed |
| pubmed-article:18185515 | pubmed:author | pubmed-author:SundaramMeera... | lld:pubmed |
| pubmed-article:18185515 | pubmed:author | pubmed-author:ZimmermanJohn... | lld:pubmed |
| pubmed-article:18185515 | pubmed:author | pubmed-author:RaizenDavid... | lld:pubmed |
| pubmed-article:18185515 | pubmed:author | pubmed-author:YouYoung-jaiY... | lld:pubmed |
| pubmed-article:18185515 | pubmed:author | pubmed-author:MaycockMatthe... | lld:pubmed |
| pubmed-article:18185515 | pubmed:author | pubmed-author:TaUyen DUD | lld:pubmed |
| pubmed-article:18185515 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18185515 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:18185515 | pubmed:volume | 451 | lld:pubmed |
| pubmed-article:18185515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18185515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18185515 | pubmed:pagination | 569-72 | lld:pubmed |
| pubmed-article:18185515 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:18185515 | pubmed:meshHeading | pubmed-meshheading:18185515... | lld:pubmed |
| pubmed-article:18185515 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18185515 | pubmed:articleTitle | Lethargus is a Caenorhabditis elegans sleep-like state. | lld:pubmed |
| pubmed-article:18185515 | pubmed:affiliation | Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA. raizen@mail.med.upenn.edu | lld:pubmed |
| pubmed-article:18185515 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18185515 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18185515 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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