| pubmed-article:18174919 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C1955260 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0538205 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C0026559 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:18174919 | lifeskim:mentions | umls-concept:C2347946 | lld:lifeskim |
| pubmed-article:18174919 | pubmed:dateCreated | 2008-1-4 | lld:pubmed |
| pubmed-article:18174919 | pubmed:abstractText | Although the importance of the progesterone receptor (PR) to female reproductive and mammary gland biology is firmly established, the coregulators selectively co-opted by PR in these systems have not been clearly delineated. A selective gene-knockout approach applied to the mouse, which abrogates gene function only in cell types that express PR, recently disclosed steroid receptor coactivator 2 (SRC-2, also known as TIF-2 or GRIP-1) to be an indispensable coregulator for uterine and mammary gland responses that require progesterone. Uterine cells positive for PR (but devoid of SRC-2) were found to be incapable of facilitating embryo implantation, a necessary first step toward the establishment of the materno-fetal interface. Importantly, such an implantation defect is not exhibited by knockouts for SRC-1 or SRC-3, underscoring the unique coregulator importance of SRC-2 in peri-implantation biology. Moreover, despite normal levels of PR, SRC-1 and SRC-3, progesterone-dependent branching morphogenesis and alveologenesis fails to occur in the murine mammary gland in the absence of SRC-2, thereby establishing a critical coregulator role for SRC-2 in signaling cascades that mediate progesterone-induced mammary epithelial proliferation. Finally, the recent detection of SRC-2 in the human endometrium and breast suggests that this coregulator may represent a new clinical target for the future management of female reproductive health and/or breast cancer. | lld:pubmed |
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| pubmed-article:18174919 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18174919 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18174919 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18174919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18174919 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18174919 | pubmed:issn | 1550-7629 | lld:pubmed |
| pubmed-article:18174919 | pubmed:author | pubmed-author:AmatoPaulaP | lld:pubmed |
| pubmed-article:18174919 | pubmed:author | pubmed-author:DeMayoFrances... | lld:pubmed |
| pubmed-article:18174919 | pubmed:author | pubmed-author:AllredD... | lld:pubmed |
| pubmed-article:18174919 | pubmed:author | pubmed-author:LydonJohn PJP | lld:pubmed |
| pubmed-article:18174919 | pubmed:author | pubmed-author:MukherjeeAtis... | lld:pubmed |
| pubmed-article:18174919 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18174919 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:18174919 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18174919 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18174919 | pubmed:pagination | e011 | lld:pubmed |
| pubmed-article:18174919 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:meshHeading | pubmed-meshheading:18174919... | lld:pubmed |
| pubmed-article:18174919 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18174919 | pubmed:articleTitle | Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human. | lld:pubmed |
| pubmed-article:18174919 | pubmed:affiliation | Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. | lld:pubmed |
| pubmed-article:18174919 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18174919 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:18174919 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
