| pubmed-article:18172165 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18172165 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:18172165 | lifeskim:mentions | umls-concept:C0019652 | lld:lifeskim |
| pubmed-article:18172165 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:18172165 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:18172165 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18172165 | lifeskim:mentions | umls-concept:C0332283 | lld:lifeskim |
| pubmed-article:18172165 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:18172165 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18172165 | pubmed:dateCreated | 2008-1-3 | lld:pubmed |
| pubmed-article:18172165 | pubmed:abstractText | Histone mRNAs are rapidly degraded at the end of S phase or when DNA replication is inhibited. Histone mRNAs end in a conserved stem-loop rather than a poly(A) tail. Degradation of histone mRNAs requires the stem-loop sequence, which binds the stem-loop-binding protein (SLBP), active translation of the histone mRNA, and the location of the stem-loop close to the termination codon. We report that the initial step in histone mRNA degradation is the addition of uridines to the 3' end of the histone mRNA, both after inhibition of DNA replication and at the end of S phase. Lsm1 is required for histone mRNA degradation and is present in a complex containing SLBP on the 3' end of histone mRNA after inhibition of DNA replication. We cloned degradation intermediates that had been partially degraded from both the 5' and the 3' ends. RNAi experiments demonstrate that both the exosome and 5'-to-3' decay pathway components are required for degradation, and individual histone mRNAs are then degraded simultaneously 5' to 3' and 3' to 5'. | lld:pubmed |
| pubmed-article:18172165 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18172165 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18172165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18172165 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18172165 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18172165 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:18172165 | pubmed:author | pubmed-author:MarzluffWilli... | lld:pubmed |
| pubmed-article:18172165 | pubmed:author | pubmed-author:MullenThomas... | lld:pubmed |
| pubmed-article:18172165 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18172165 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18172165 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:18172165 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18172165 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18172165 | pubmed:pagination | 50-65 | lld:pubmed |
| pubmed-article:18172165 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18172165 | pubmed:meshHeading | pubmed-meshheading:18172165... | lld:pubmed |
| pubmed-article:18172165 | pubmed:meshHeading | pubmed-meshheading:18172165... | lld:pubmed |
| pubmed-article:18172165 | pubmed:meshHeading | pubmed-meshheading:18172165... | lld:pubmed |
