| pubmed-article:18166151 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18166151 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:18166151 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:18166151 | lifeskim:mentions | umls-concept:C0031308 | lld:lifeskim |
| pubmed-article:18166151 | lifeskim:mentions | umls-concept:C0027270 | lld:lifeskim |
| pubmed-article:18166151 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:18166151 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:18166151 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18166151 | pubmed:dateCreated | 2008-1-18 | lld:pubmed |
| pubmed-article:18166151 | pubmed:abstractText | NAD is available in the extracellular environment and elicits immune modulation such as T cell apoptosis by being used as the substrate of cell surface ADP-ribosyl transferase. However, it is unclear whether extracellular NAD affects function of macrophages expressing cell surface ADP-ribosyl transferase. Here we show that extracellular NAD enhances Fcgamma receptor (FcgammaR)-mediated phagocytosis in J774A.1 macrophages via the conversion into cyclic ADP-ribose (cADPR), a potent calcium mobilizer, by CD38, an ADP-ribosyl cyclase. Extracellular NAD increased the phagocytosis of IgG-coated sheep red blood cells (IgG-SRBC) in J774A.1 macrophages, which was completely abolished by pretreatment of 8-bromo-cADPR, an antagonist of cADPR, or CD38 knockdown. Extracellular NAD increased basal intracellular Ca(2+) concentration, which also was abolished by pretreatment of 8-bromo-cADPR or CD38 knockdown. Moreover, the chelation of intracellular calcium abolished NAD-induced enhancement of phagocytosis of IgG-SRBC. Our results suggest that extracellular NAD act as a regulator for FcgammaR-mediated phagocytosis in macrophages. | lld:pubmed |
| pubmed-article:18166151 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18166151 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166151 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18166151 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166151 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166151 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166151 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166151 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166151 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166151 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18166151 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18166151 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:HanMyung-Kwan... | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:ParkKwang-Hyu... | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:KimUh-HyunUH | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:KimJong-SukJS | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:LeeSeung-JinS... | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:SongEun-Kyung... | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:LeeYoung-RaeY... | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:ParkYeong-Min... | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:RahSo-YoungSY | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:YuHong-NuHN | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:ShimIn-KyungI... | lld:pubmed |
| pubmed-article:18166151 | pubmed:author | pubmed-author:ChungWeon-Guu... | lld:pubmed |
| pubmed-article:18166151 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18166151 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:18166151 | pubmed:volume | 367 | lld:pubmed |
| pubmed-article:18166151 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18166151 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18166151 | pubmed:pagination | 156-61 | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:meshHeading | pubmed-meshheading:18166151... | lld:pubmed |
| pubmed-article:18166151 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18166151 | pubmed:articleTitle | Extracellular NAD is a regulator for FcgammaR-mediated phagocytosis in murine macrophages. | lld:pubmed |
| pubmed-article:18166151 | pubmed:affiliation | Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju 561-182, South Korea. | lld:pubmed |
| pubmed-article:18166151 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18166151 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18166151 | lld:pubmed |
