| pubmed-article:18166081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18166081 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:18166081 | lifeskim:mentions | umls-concept:C0259902 | lld:lifeskim |
| pubmed-article:18166081 | lifeskim:mentions | umls-concept:C2827477 | lld:lifeskim |
| pubmed-article:18166081 | lifeskim:mentions | umls-concept:C1160070 | lld:lifeskim |
| pubmed-article:18166081 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:18166081 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18166081 | pubmed:dateCreated | 2008-1-1 | lld:pubmed |
| pubmed-article:18166081 | pubmed:abstractText | Mammalian Argonaute proteins (EIF2C1-4) play an essential role in RNA-induced silencing. Here, we show that the loss of eIF2C2 (Argonaute2 or Ago2) results in gastrulation arrest, ectopic expression of Brachyury (T), and mesoderm expansion. We identify a genetic interaction between Ago2 and T, as Ago2 haploinsufficiency partially rescues the classic T/+ short-tail phenotype. Finally, we demonstrate that the ectopic T expression and concomitant mesoderm expansion result from disrupted fibroblast growth factor signaling, likely due to aberrant expression of Eomesodermin. Together, these data indicate that a factor best known as a key component of the RNA-induced silencing complex is required for proper fibroblast growth factor signaling during gastrulation, suggesting a possible micro-RNA function in the formation of a mammalian germ layer. | lld:pubmed |
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| pubmed-article:18166081 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18166081 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18166081 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18166081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18166081 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18166081 | pubmed:issn | 1553-7404 | lld:pubmed |
| pubmed-article:18166081 | pubmed:author | pubmed-author:Ped'L MLM | lld:pubmed |
| pubmed-article:18166081 | pubmed:author | pubmed-author:WarrenStephen... | lld:pubmed |
| pubmed-article:18166081 | pubmed:author | pubmed-author:CasparyTamara... | lld:pubmed |
| pubmed-article:18166081 | pubmed:author | pubmed-author:AlischReid... | lld:pubmed |
| pubmed-article:18166081 | pubmed:author | pubmed-author:EpsteinMichae... | lld:pubmed |
| pubmed-article:18166081 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18166081 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:18166081 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:18166081 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18166081 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18166081 | pubmed:pagination | e227 | lld:pubmed |
| pubmed-article:18166081 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:18166081 | pubmed:meshHeading | pubmed-meshheading:18166081... | lld:pubmed |
| pubmed-article:18166081 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18166081 | pubmed:articleTitle | Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation. | lld:pubmed |
| pubmed-article:18166081 | pubmed:affiliation | Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America. | lld:pubmed |
| pubmed-article:18166081 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18166081 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18166081 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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