Linked Life Data

18164693

Source:http://linkedlifedata.com/resource/pubmed/id/18164693

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pubmed-article:18164693pubmed:abstractTextA domain (RKKRRQRRR) derived from HIV-1 Tat is one of the most efficient protein transduction domains (PTD) for delivering macromolecules including proteins into cells and tissues. Antioxidant enzymes such as superoxide dismutase (SOD) and catalase are major cellular defenses against oxidative stress which results in various diseases including skin inflammation. In this study, we examined the effect of SOD fused with HIV-1 Tat PTD (Tat-SOD) on TPA-induced skin inflammation in mice. Topical application of Tat-SOD to mice ears 1h after TPA application once a day for 3 days dose-dependently inhibited TPA-induced ear edema in mice. Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2). Furthermore, topical application of Tat-SOD resulted in significant reduction in activation of NF-kappaB and mitogen-activated protein kinases (MAPK) in the mice ears treated with TPA. These data demonstrates that Tat-SOD inhibits TPA-induced inflammation in mice by reducing the levels of expression of proinflammatory cytokines and enzymes regulated by the NF-kappaB and MAPK and can be used as a therapeutic agent against skin inflammation related to oxidative damage.lld:pubmed
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pubmed-article:18164693pubmed:authorpubmed-author:ChoiSoo...lld:pubmed
pubmed-article:18164693pubmed:authorpubmed-author:WonMoo HoMHlld:pubmed
pubmed-article:18164693pubmed:authorpubmed-author:ParkJinseuJlld:pubmed
pubmed-article:18164693pubmed:authorpubmed-author:JangSang HoSHlld:pubmed
pubmed-article:18164693pubmed:authorpubmed-author:EumWon SikWSlld:pubmed
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pubmed-article:18164693pubmed:authorpubmed-author:YooKi-YeonKYlld:pubmed
pubmed-article:18164693pubmed:authorpubmed-author:JuSung MiSMlld:pubmed
pubmed-article:18164693pubmed:authorpubmed-author:SongHa YongHYlld:pubmed
pubmed-article:18164693pubmed:authorpubmed-author:LeeJi AeJAlld:pubmed
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pubmed-article:18164693pubmed:year2008lld:pubmed
pubmed-article:18164693pubmed:articleTitleTopical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.lld:pubmed
pubmed-article:18164693pubmed:affiliationDepartment of Biomedical Science, Hallym University, 1 Okchun-dong, Chunchon, Kangwon-Do 200-702, Republic of Korea.lld:pubmed
pubmed-article:18164693pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18164693pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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