| pubmed-article:18158901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18158901 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18158901 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:18158901 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18158901 | lifeskim:mentions | umls-concept:C1158537 | lld:lifeskim |
| pubmed-article:18158901 | lifeskim:mentions | umls-concept:C1420865 | lld:lifeskim |
| pubmed-article:18158901 | lifeskim:mentions | umls-concept:C1427378 | lld:lifeskim |
| pubmed-article:18158901 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18158901 | pubmed:dateCreated | 2007-12-26 | lld:pubmed |
| pubmed-article:18158901 | pubmed:abstractText | Phosphorylated histone H2AX ("gamma-H2AX") recruits MDC1, 53BP1, and BRCA1 to chromatin near a double-strand break (DSB) and facilitates efficient repair of the break. It is unclear to what extent gamma-H2AX-associated proteins act in concert and to what extent their functions within gamma-H2AX chromatin are distinct. We addressed this question by comparing the mechanisms of action of MDC1 and 53BP1 in DSB repair (DSBR). We find that MDC1 functions primarily in homologous recombination/sister chromatid recombination, in a manner strictly dependent upon its ability to interact with gamma-H2AX but, unexpectedly, not requiring recruitment of 53BP1 or BRCA1 to gamma-H2AX chromatin. In contrast, 53BP1 functions in XRCC4-dependent nonhomologous end-joining, likely mediated by its interaction with dimethylated lysine 20 of histone H4 but, surprisingly, independent of H2AX. These results suggest a specialized adaptation of the "histone code" in which distinct histone tail-protein interactions promote engagement of distinct DSBR pathways. | lld:pubmed |
| pubmed-article:18158901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18158901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18158901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18158901 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18158901 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:AltFrederick... | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:ChenJunjieJ | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:PugetNadineN | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:ScullyRalphR | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:JacksonStephe... | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:YanCatherineC | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:StuckiManuelM | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:XieAnyongA | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:NagarajuGanes... | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:OdateShobuS | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:KwokAmyA | lld:pubmed |
| pubmed-article:18158901 | pubmed:author | pubmed-author:HartlerodeAnd... | lld:pubmed |
| pubmed-article:18158901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18158901 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:18158901 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:18158901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18158901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18158901 | pubmed:pagination | 1045-57 | lld:pubmed |
| pubmed-article:18158901 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
