| pubmed-article:1812956 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1812956 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1812956 | lifeskim:mentions | umls-concept:C0033618 | lld:lifeskim |
| pubmed-article:1812956 | lifeskim:mentions | umls-concept:C0022635 | lld:lifeskim |
| pubmed-article:1812956 | lifeskim:mentions | umls-concept:C0032120 | lld:lifeskim |
| pubmed-article:1812956 | lifeskim:mentions | umls-concept:C0178742 | lld:lifeskim |
| pubmed-article:1812956 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:1812956 | lifeskim:mentions | umls-concept:C0599473 | lld:lifeskim |
| pubmed-article:1812956 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1812956 | pubmed:dateCreated | 1992-6-16 | lld:pubmed |
| pubmed-article:1812956 | pubmed:abstractText | The protein binding of ketoprofen enantiomers was investigated in human plasma at physiological pH and temperature by ultrafiltration. 14C-labelled (RS)-ketoprofen was synthesized and purified by high-performance liquid chromatography and utilized as a means of quantifying the unbound species. In vitro studies were conducted with plasma obtained from six healthy volunteers. The plasma was spiked with (R)-ketoprofen alone, (S)-ketoprofen alone, and (RS)-ketoprofen in the enantiomeric concentration range of 1.0 to 19.0 micrograms/ml. The plasma protein binding of ketoprofen was nonenantioselective. At a racemic drug concentration of 2.0 micrograms/ml the mean (+/- SD) percentage unbound of (R)-ketoprofen was 0.80 (+/- 0.15)%. The corresponding value for (S)-ketoprofen, 0.78 (+/- 0.18)%, was not statistically different (P greater than 0.05). At this racemic drug concentration (2.0 micrograms/ml) the percentage unbound of each enantiomer was unaffected (P greater than 0.05) by the presence of the glucuronoconjugates of ketoprofen (10 micrograms/ml) in plasma. At clinically relevant concentrations, the plasma binding of ketoprofen did not exhibit enantioselectivity or concentration dependence nor was the binding of either enantiomer influenced by its optical antipode (P greater than 0.05). | lld:pubmed |
| pubmed-article:1812956 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1812956 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1812956 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1812956 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1812956 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1812956 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1812956 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1812956 | pubmed:issn | 0899-0042 | lld:pubmed |
| pubmed-article:1812956 | pubmed:author | pubmed-author:BochnerFF | lld:pubmed |
| pubmed-article:1812956 | pubmed:author | pubmed-author:NationR LRL | lld:pubmed |
| pubmed-article:1812956 | pubmed:author | pubmed-author:HayballP JPJ | lld:pubmed |
| pubmed-article:1812956 | pubmed:author | pubmed-author:HamonD PDP | lld:pubmed |
| pubmed-article:1812956 | pubmed:author | pubmed-author:NewtonJ LJL | lld:pubmed |
| pubmed-article:1812956 | pubmed:author | pubmed-author:Massy-Westrop... | lld:pubmed |
| pubmed-article:1812956 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1812956 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:1812956 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1812956 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1812956 | pubmed:pagination | 460-6 | lld:pubmed |
| pubmed-article:1812956 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:meshHeading | pubmed-meshheading:1812956-... | lld:pubmed |
| pubmed-article:1812956 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1812956 | pubmed:articleTitle | Plasma protein binding of ketoprofen enantiomers in man: method development and its application. | lld:pubmed |
| pubmed-article:1812956 | pubmed:affiliation | Pharmacy Department, Repatriation General Hospital, Daw Park, South Australia. | lld:pubmed |
| pubmed-article:1812956 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1812956 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1812956 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1812956 | lld:pubmed |
