| pubmed-article:1810602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0079469 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:1810602 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:1810602 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1810602 | pubmed:dateCreated | 1992-6-3 | lld:pubmed |
| pubmed-article:1810602 | pubmed:abstractText | 1. The interaction between inositol 1,4,5-trisphosphate (InsP3) and guanosine 5'-O-(3-thio triphosphate) (GTP gamma S) releasable calcium (Ca2+) pools was examined using 45Ca effluxes in permeabilized cultured airway smooth muscle cells from rabbit trachea. 2. Addition of InsP3 or GTP gamma S caused a concentration-dependent release of intracellular Ca2+. The release of Ca2+ by InsP3 was much greater than with GTP gamma S. Pretreatment with maximally effective InsP3 (10 microM) abolished the GTP gamma S-induced Ca2+ release, whereas pretreatment with 100 microM GTP gamma S reduced the InsP3-induced Ca2+ release by 25%. 3. Ryanodine (100 microM), also gave a large release of intracellular Ca2+. After pretreatment with 100 microM ryanodine, GTP gamma S did not induce Ca2+ release, and InsP3-induced Ca2+ release was reduced by 76%. 4. Caffeine (50 mM), produced a slow release of intracellular Ca2+. Pre-exposure to 50 mM caffeine had no effect on the GTP gamma S-induced Ca2+ release but reduced the InsP3 releasable Ca2+ by 58%. 5. Pretreatment with ryanodine abolished the caffeine-induced Ca2+ release, and addition of caffeine before ryanodine reduced the ryanodine-induced Ca2+ release by 64.4%. 6. These results suggest that there are at least three pools of Ca2+ present within airway smooth muscle cells. The largest pool is released by InsP3 or ryanodine, another is released either by a high concentration of InsP3 or on application of GTP gamma S, and the third by InsP3 alone. Ca2+ may be able to move from the GTP gamma S-sensitive pool into the InsP3- and ryanodine-sensitive pool when this becomes depleted. In contrast, the opposite movement of Ca2 + cannot occur. | lld:pubmed |
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| pubmed-article:1810602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1810602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1810602 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1810602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1810602 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1810602 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:1810602 | pubmed:author | pubmed-author:CameronI RIR | lld:pubmed |
| pubmed-article:1810602 | pubmed:author | pubmed-author:WardJ PJP | lld:pubmed |
| pubmed-article:1810602 | pubmed:author | pubmed-author:TwortC HCH | lld:pubmed |
| pubmed-article:1810602 | pubmed:author | pubmed-author:ChopraL CLC | lld:pubmed |
| pubmed-article:1810602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1810602 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:1810602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1810602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1810602 | pubmed:pagination | 901-6 | lld:pubmed |
| pubmed-article:1810602 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1810602 | pubmed:meshHeading | pubmed-meshheading:1810602-... | lld:pubmed |
| pubmed-article:1810602 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1810602 | pubmed:articleTitle | Inositol 1,4,5-trisphosphate- and guanosine 5'-O-(3-thiotriphosphate)-induced Ca2+ release in cultured airway smooth muscle. | lld:pubmed |
| pubmed-article:1810602 | pubmed:affiliation | Division of Medicine, United Medical School, Guy's Hospital, London. | lld:pubmed |
| pubmed-article:1810602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1810602 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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