Linked Life Data

18097665

Source:http://linkedlifedata.com/resource/pubmed/id/18097665

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pubmed-article:18097665pubmed:abstractTextMelan-A/MART1 is a melanocytic differentiation antigen recognized on melanoma tumor cells by CD8+ and CD4+ T cells. In this study, we describe a new epitope of this protein recognized in the context of HLA-Cw*0701 molecules by a CD8+ tumor infiltrating lymphocyte (TIL) clone. This CD8+ TIL clone specifically recognized and killed a fraction of melanoma cells lines expressing Melan-A/MART1 and HLA-Cw*0701. We further show that the Melan-A/MART1(51-61) peptide is the optimal peptide recognized by this clone. Together, these data significantly enlarge the fraction of melanoma patients susceptible to benefit from a Melan-A/MART1 vaccine approach.lld:pubmed
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pubmed-article:18097665pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:18097665pubmed:articleTitleA HLA-Cw*0701 restricted Melan-A/MART1 epitope presented by melanoma tumor cells to CD8+ tumor infiltrating lymphocytes.lld:pubmed
pubmed-article:18097665pubmed:affiliationInstitut de biologie, 9 quai moncousu, 44093, Nantes Cedex, France.lld:pubmed
pubmed-article:18097665pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18097665pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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