|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0030685,
umls-concept:C0034809,
umls-concept:C0035143,
umls-concept:C0036849,
umls-concept:C0040715,
umls-concept:C0086860,
umls-concept:C0280141,
umls-concept:C0391871,
umls-concept:C0449432,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C0680255,
umls-concept:C0699748,
umls-concept:C1137947,
umls-concept:C1179435,
umls-concept:C1283071,
umls-concept:C1301676,
umls-concept:C1442518,
umls-concept:C1522702,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1552652,
umls-concept:C1552685,
umls-concept:C1705195,
umls-concept:C1705230,
umls-concept:C1705248,
umls-concept:C1841971,
umls-concept:C1879547,
umls-concept:C1963578
|
|
pubmed:issue |
1-2
|
|
pubmed:dateCreated |
2008-2-18
|
|
pubmed:abstractText |
Set/template-activating factor (TAF)-Ibeta, part of the Set-Can oncogene product found in acute undifferentiated leukemia, is a component of the inhibitor of acetyltransferases (INHAT) complex. Set/TAF-Ibeta interacted with the DNA-binding domain of the glucocorticoid receptor (GR) in yeast two-hybrid screening, and repressed GR-induced transcriptional activity of a chromatin-integrated glucocorticoid-responsive and a natural promoter. Set/TAF-Ibeta was co-precipitated with glucocorticoid response elements (GREs) of these promoters in the absence of dexamethasone, while addition of the hormone caused dissociation of Set/TAF-Ibeta from and attraction of the p160-type coactivator GRIP1 to the promoter GREs. Set-Can fusion protein, on the other hand, did not interact with GR, was constitutively co-precipitated with GREs and suppressed GRIP1-induced enhancement of GR transcriptional activity and histone acetylation. Thus, Set/TAF-Ibeta acts as a ligand-activated GR-responsive transcriptional repressor, while Set-Can does not retain physiologic responsiveness to ligand-bound GR, possibly contributing to the poor responsiveness of Set-Can-harboring leukemic cells to glucocorticoids.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-10362532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-10368774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-10390352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-10439365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-11163245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-11978794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-12444143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-12511607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-12596910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-12759364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-12943736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-1384675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-14612398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-14739255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15100215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15136563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15242344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15243581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15632079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15708996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15769988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-15955845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-16195249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-16249187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-1630450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-2160080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-2881624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-7715646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-7753551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-7753797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-8141124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-8486711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-8895527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-9773788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-9852120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18096310-9874563
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Chaperones,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucocorticoid,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SET protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SET-CAN fusion protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0303-7207
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
13
|
|
pubmed:volume |
283
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
19-31
|
|
pubmed:dateRevised |
2011-4-25
|
|
pubmed:meshHeading |
pubmed-meshheading:18096310-Animals,
pubmed-meshheading:18096310-Chromatin Immunoprecipitation,
pubmed-meshheading:18096310-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:18096310-Drug Resistance, Neoplasm,
pubmed-meshheading:18096310-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18096310-Glucocorticoids,
pubmed-meshheading:18096310-HCT116 Cells,
pubmed-meshheading:18096310-Histone Acetyltransferases,
pubmed-meshheading:18096310-Histone Chaperones,
pubmed-meshheading:18096310-Humans,
pubmed-meshheading:18096310-Leukemia,
pubmed-meshheading:18096310-Ligands,
pubmed-meshheading:18096310-Models, Genetic,
pubmed-meshheading:18096310-Nuclear Proteins,
pubmed-meshheading:18096310-Oncogene Proteins, Fusion,
pubmed-meshheading:18096310-Phosphoproteins,
pubmed-meshheading:18096310-Promoter Regions, Genetic,
pubmed-meshheading:18096310-Protein Binding,
pubmed-meshheading:18096310-Protein Structure, Tertiary,
pubmed-meshheading:18096310-Rats,
pubmed-meshheading:18096310-Receptors, Glucocorticoid,
pubmed-meshheading:18096310-Repressor Proteins,
pubmed-meshheading:18096310-Response Elements,
pubmed-meshheading:18096310-Transcription, Genetic,
pubmed-meshheading:18096310-Transcription Factors,
pubmed-meshheading:18096310-Translocation, Genetic
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Ibeta and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiated leukemia with Set-Can translocation.
|
|
pubmed:affiliation |
Section on Pediatric Endocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1109, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
|
