| pubmed-article:18095113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18095113 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:18095113 | lifeskim:mentions | umls-concept:C0079427 | lld:lifeskim |
| pubmed-article:18095113 | lifeskim:mentions | umls-concept:C0033375 | lld:lifeskim |
| pubmed-article:18095113 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18095113 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:18095113 | lifeskim:mentions | umls-concept:C0919432 | lld:lifeskim |
| pubmed-article:18095113 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:18095113 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18095113 | pubmed:dateCreated | 2007-12-20 | lld:pubmed |
| pubmed-article:18095113 | pubmed:abstractText | The presence of transforming growth factor-beta receptor type II and Smad3 gene abnormality was examined in human prolactinomas by single-strand conformation polymorphism screening for gene abnormality and band shift in tumor tissue and peripheral blood samples obtained from 14 patients treated for prolactinoma. Direct sequencing of exon 4 of the transforming growth factor-beta receptor type II gene, which showed a band shift by single-strand conformation polymorphism, disclosed a single nucleotide polymorphism (rs2228048) (alleles A/G; average allele frequency, G:0.817, A:0.183) and not an active mutation. Seven of the 14 cases showed base substitution (G --> A) of the single nucleotide polymorphism. Two of these 7 cases showed base substitution (G --> A) in the blood sample in accordance with neoplastic transformation. Direct sequencing of exon 2 of the Smad3 gene, which showed band shift by single-strand conformation polymorphism, disclosed single nucleotide polymorphism (rs1065080) (alleles C/T; average allele frequency, C:0.947, T:0.053) and no active mutation. Four of the 14 cases showed base substitution (C --> T) of the single nucleotide polymorphism. Blood samples were available for 2 of these 4 cases, and 1 of these 2 cases showed base substitution (C --> T) in accordance with neoplastic transformation. Estimation of the drug sensitivity of pituitary adenoma based on analysis of peripheral blood cells needs special care. | lld:pubmed |
| pubmed-article:18095113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18095113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18095113 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18095113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18095113 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:18095113 | pubmed:issn | 1433-7398 | lld:pubmed |
| pubmed-article:18095113 | pubmed:author | pubmed-author:IkedaHidetosh... | lld:pubmed |
| pubmed-article:18095113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18095113 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:18095113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18095113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18095113 | pubmed:pagination | 7-12 | lld:pubmed |
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| pubmed-article:18095113 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:18095113 | pubmed:articleTitle | Mutational analysis of transforming growth factor-beta receptor type II and Smad3 tumor suppressor genes in prolactinomas. | lld:pubmed |
| pubmed-article:18095113 | pubmed:affiliation | Department of Neurosurgery, Kohnan Hospital, Sendai, Japan. ikeda@nsg.med.tohoku.ac.jp | lld:pubmed |
| pubmed-article:18095113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18095113 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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