| pubmed-article:18094026 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C0032214 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C0600138 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C1335843 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C2610445 | lld:lifeskim |
| pubmed-article:18094026 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:18094026 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18094026 | pubmed:dateCreated | 2008-1-14 | lld:pubmed |
| pubmed-article:18094026 | pubmed:abstractText | ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play important roles in a number of developmental processes. SWI/SNF-like chromatin-remodeling complexes use one of two different ATPases as their catalytic subunit: brahma (BRM, also known as SMARCA2) and brahma-related gene 1 (BRG1, also known as SMARCA4). We have conditionally deleted a floxed Brg1 allele with a Tie2-Cre transgene, which is expressed in developing hematopoietic and endothelial cells. Brg1(fl/fl):Tie2-Cre(+) embryos die at midgestation from anemia, as mutant primitive erythrocytes fail to transcribe embryonic alpha- and beta-globins, and subsequently undergo apoptosis. Additionally, vascular remodeling of the extraembryonic yolk sac is abnormal in Brg1(fl/fl):Tie2-Cre(+) embryos. Importantly, Brm deficiency does not exacerbate the erythropoietic or vascular abnormalities found in Brg1(fl/fl):Tie2-Cre(+) embryos, implying that Brg1-containing SWI/SNF-like complexes, rather than Brm-containing complexes, play a crucial role in primitive erythropoiesis and in early vascular development. | lld:pubmed |
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| pubmed-article:18094026 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18094026 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18094026 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18094026 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18094026 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18094026 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:18094026 | pubmed:author | pubmed-author:MagnusonTerry... | lld:pubmed |
| pubmed-article:18094026 | pubmed:author | pubmed-author:BrennanJennif... | lld:pubmed |
| pubmed-article:18094026 | pubmed:author | pubmed-author:GriffinCourtn... | lld:pubmed |
| pubmed-article:18094026 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18094026 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:18094026 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18094026 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18094026 | pubmed:pagination | 493-500 | lld:pubmed |
| pubmed-article:18094026 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:18094026 | pubmed:meshHeading | pubmed-meshheading:18094026... | lld:pubmed |
| pubmed-article:18094026 | pubmed:meshHeading | pubmed-meshheading:18094026... | lld:pubmed |
| pubmed-article:18094026 | pubmed:meshHeading | pubmed-meshheading:18094026... | lld:pubmed |
| pubmed-article:18094026 | pubmed:meshHeading | pubmed-meshheading:18094026... | lld:pubmed |
| pubmed-article:18094026 | pubmed:meshHeading | pubmed-meshheading:18094026... | lld:pubmed |
| pubmed-article:18094026 | pubmed:meshHeading | pubmed-meshheading:18094026... | lld:pubmed |
| pubmed-article:18094026 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18094026 | pubmed:articleTitle | The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. | lld:pubmed |
| pubmed-article:18094026 | pubmed:affiliation | Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. | lld:pubmed |
| pubmed-article:18094026 | pubmed:publicationType | Journal Article | lld:pubmed |
