| pubmed-article:18084303 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18084303 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:18084303 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18084303 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:18084303 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:18084303 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:18084303 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18084303 | pubmed:dateCreated | 2008-1-7 | lld:pubmed |
| pubmed-article:18084303 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18084303 | pubmed:abstractText | The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 A between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1beta (NX1beta) LNS (laminin, neurexin and sex hormone-binding globulin-like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca2+-mediated and solvent-supplemented interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1beta interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder. | lld:pubmed |
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| pubmed-article:18084303 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18084303 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18084303 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18084303 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18084303 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18084303 | pubmed:issn | 1545-9985 | lld:pubmed |
| pubmed-article:18084303 | pubmed:author | pubmed-author:ChenXiaoyanX | lld:pubmed |
| pubmed-article:18084303 | pubmed:author | pubmed-author:FociaPamela... | lld:pubmed |
| pubmed-article:18084303 | pubmed:author | pubmed-author:LiuHeliH | lld:pubmed |
| pubmed-article:18084303 | pubmed:author | pubmed-author:HeXiaolinX | lld:pubmed |
| pubmed-article:18084303 | pubmed:author | pubmed-author:ShimAnn H RAH | lld:pubmed |
| pubmed-article:18084303 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18084303 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:18084303 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18084303 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18084303 | pubmed:pagination | 50-6 | lld:pubmed |
| pubmed-article:18084303 | pubmed:dateRevised | 2011-9-7 | lld:pubmed |
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| pubmed-article:18084303 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18084303 | pubmed:articleTitle | Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. | lld:pubmed |
| pubmed-article:18084303 | pubmed:affiliation | Northwestern University Feinberg School of Medicine, Department of Molecular Pharmacology & Biological Chemistry, Searle 8-417, 303 East Chicago Avenue, Chicago, Illinois 60611, USA. | lld:pubmed |
| pubmed-article:18084303 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18084303 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18084303 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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