Linked Life Data

18082937

Source:http://linkedlifedata.com/resource/pubmed/id/18082937

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pubmed-article:18082937pubmed:abstractTextRecent pharmacogenetic studies on irinotecan have revealed the impact of UDP glucuronosyltransferase (UGT) 1A1*28 on severe irinotecan toxicities. Although the clinical role of UGT1A1*6, which is specifically detected in East Asian patients, in irinotecan toxicities is suggested, clear evidence remains limited. To examine the impact of *6, the association of UGT1A1 genotypes with severe irinotecan toxicities was retrospectively investigated in Japanese cancer patients. A significant *6-dependent increase in the incidence of grade 3 or 4 neutropenia was observed in 49 patients on irinotecan monotherapy (p=0.012). This study further clarifies the clinical importance of *6 in irinotecan therapy in East Asians.lld:pubmed
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pubmed-article:18082937pubmed:articleTitleImportance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients.lld:pubmed
pubmed-article:18082937pubmed:affiliationDivision of Biosignaling, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. sai@nihs.go.jplld:pubmed
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