| pubmed-article:18078311 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C0034255 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C0332461 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C2353566 | lld:lifeskim |
| pubmed-article:18078311 | lifeskim:mentions | umls-concept:C0599278 | lld:lifeskim |
| pubmed-article:18078311 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18078311 | pubmed:dateCreated | 2008-1-3 | lld:pubmed |
| pubmed-article:18078311 | pubmed:abstractText | 6-Thiolato-substituted 2-(4'- N,N-dimethylamino)phenylimidazo[1,2- a]pyridines ( RS-IMPYs; 1- 4) were synthesized as candidates for labeling with carbon-11 ( t 1/2 = 20.4 min) and imaging of A beta plaques in living human brain using positron emission tomography (PET). K i values for binding of these ligands to Alzheimer's disease brain homogenates were measured in vitro against tritium-labeled 6 (Pittsburgh compound B). MeS-IMPY ( 3, K i = 7.93 nM) was labeled with carbon-11 at its S- or N-methyl position to give [ (11)C] 7 or [ (11)C] 8, respectively. After injection into rats, [ (11)C] 7 or [ (11)C] 8 gave moderately high brain uptakes of radioactivity followed by rapid washout to low levels. The ratio of radioactivity at maximal uptake to that at 60 min reached 18.7 for [ (11)C] 7. [ (11)C] 7 behaved similarly in mouse and monkey. [ (11)C] 7 also bound selectively to A beta plaques in post mortem human Alzheimer's disease brain. Although rapidly metabolized in rat by N-demethylation, [ (11)C] 7 was stable in rat brain homogenates. The ex vivo brain radiometabolites observed in rats have a peripheral origin. Overall, [ (11)C] 7 merits further evaluation in human subjects. | lld:pubmed |
| pubmed-article:18078311 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078311 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18078311 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078311 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18078311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078311 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18078311 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18078311 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18078311 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:KallarS KSK | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:LiowJeih-SanJ... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:ZoghbiSami... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:InnisRobert... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:HermanMary... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:PikeVictor... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:SenecaNichola... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:CaiLishengL | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:ShettyH... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:HongJinsooJ | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:BrownAmira... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:GladdingRober... | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:BaetasCesarC | lld:pubmed |
| pubmed-article:18078311 | pubmed:author | pubmed-author:TemmeSebastia... | lld:pubmed |
| pubmed-article:18078311 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18078311 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:18078311 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:18078311 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18078311 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18078311 | pubmed:pagination | 148-58 | lld:pubmed |
| pubmed-article:18078311 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18078311 | pubmed:meshHeading | pubmed-meshheading:18078311... | lld:pubmed |
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| pubmed-article:18078311 | pubmed:meshHeading | pubmed-meshheading:18078311... | lld:pubmed |
| pubmed-article:18078311 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18078311 | pubmed:articleTitle | Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease. | lld:pubmed |
| pubmed-article:18078311 | pubmed:affiliation | Molecular Imaging Branch and Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA. cail@intra.nimh.nih.gov | lld:pubmed |
| pubmed-article:18078311 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18078311 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:18078311 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18078311 | lld:chembl |
