| pubmed-article:18070719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18070719 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:18070719 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:18070719 | lifeskim:mentions | umls-concept:C0026764 | lld:lifeskim |
| pubmed-article:18070719 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:18070719 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18070719 | pubmed:dateCreated | 2007-12-11 | lld:pubmed |
| pubmed-article:18070719 | pubmed:abstractText | Despite significant improvements in survival for multiple myeloma patients through autologous stem-cell transplantation (SCT) and the introduction of novel drugs, the disease remains incurable for all but a small fraction of patients. Only allogeneic SCT is potentially curative, due in part to a graft-versus-myeloma effect. High transplant-related mortality with allogeneic SCT is currently the major limitation to wider use of this potentially curative modality. Mortality can be reduced through the use of lower-intensity conditioning regimens which allow engraftment of allogeneic stem cells, but this comes at a cost of higher rates of disease progression and relapse. Promising studies to improve outcomes of allogeneic transplants include the use of more intensive non-myeloablative conditioning regimens, tandem transplants, peripheral blood cells, graft engineering to improve the graft-versus-myeloma activity while reducing graft-versus-host disease (GVHD), post-transplant maintenance, and targeted conditioning therapies such as bone-seeking radioisotopes. | lld:pubmed |
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| pubmed-article:18070719 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18070719 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18070719 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18070719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18070719 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18070719 | pubmed:issn | 1521-6926 | lld:pubmed |
| pubmed-article:18070719 | pubmed:author | pubmed-author:BensingerWill... | lld:pubmed |
| pubmed-article:18070719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18070719 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:18070719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18070719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18070719 | pubmed:pagination | 783-95 | lld:pubmed |
| pubmed-article:18070719 | pubmed:dateRevised | 2011-7-20 | lld:pubmed |
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| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:meshHeading | pubmed-meshheading:18070719... | lld:pubmed |
| pubmed-article:18070719 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18070719 | pubmed:articleTitle | Is there still a role for allogeneic stem-cell transplantation in multiple myeloma? | lld:pubmed |
| pubmed-article:18070719 | pubmed:affiliation | University of Washington, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D5-390, Seattle, WA 98109, USA. wbensing@fhcrc.org | lld:pubmed |
| pubmed-article:18070719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18070719 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:18070719 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18070719 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
