Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter.

Source:http://linkedlifedata.com/resource/pubmed/id/18065760

J. Biol. Chem. 2008 Feb 22 283 8 4850-65

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18065760