| pubmed-article:18064431 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C1179187 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0252528 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:18064431 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:18064431 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18064431 | pubmed:dateCreated | 2008-11-26 | lld:pubmed |
| pubmed-article:18064431 | pubmed:abstractText | Galectins have recently emerged as central regulators of the immune system. We have previously demonstrated that carbohydrate-dependent binding of galectin-2 induces apoptosis in activated T cells. Here, we investigate the potential therapeutic effect of galectin-2 in experimental colitis. Galectin-2 expression and its binding profile were determined by immunohistochemistry. Acute and chronic colitis was induced by dextran sodium sulfate administration and in a T-cell transfer colitis model. Apoptosis was assessed by TdT-mediated dUTP-biotin nick-end labeling, and cytokine secretion was determined by cytometric bead array. We show that galectin-2 was constitutively expressed mainly in the epithelial compartment of the mouse intestine and bind to lamina propria mononuclear cells. During colitis, galectin-2 expression was reduced, but could be restored to normal levels by immunosuppressive treatment. Galectin-2 treatment induced apoptosis of mucosal T cells and thus ameliorated acute and chronic dextran-sodium-sulfate-induced colitis and in a T-helper-cell 1-driven model of antigen-specific transfer colitis. Furthermore, the pro-inflammatory cytokine release was inhibited by galectin-2 treatment. In preliminary toxicity studies, galectin-2 was well tolerated. Our study provides evidence that galectin-2 induces apoptosis in vivo and ameliorates acute and chronic murine colitis. Furthermore, galectin-2 has no significant toxicity over a broad dose range, suggesting that it may serve as a new therapeutic agent in the treatment of inflammatory bowel disease. | lld:pubmed |
| pubmed-article:18064431 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18064431 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18064431 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18064431 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18064431 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18064431 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18064431 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18064431 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18064431 | pubmed:issn | 0946-2716 | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:WiedenmannBer... | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:RosewiczStefa... | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:DaneseSilvioS | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:SturmAndreasA | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:PaclikDaniela... | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:DignassAxel... | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:WittigBianca... | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:BerndtUtaU | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:DankofAnjaA | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:GuzyClaudiaC | lld:pubmed |
| pubmed-article:18064431 | pubmed:author | pubmed-author:HolzloehnerPa... | lld:pubmed |
| pubmed-article:18064431 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18064431 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:18064431 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18064431 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18064431 | pubmed:pagination | 1395-406 | lld:pubmed |
| pubmed-article:18064431 | pubmed:dateRevised | 2011-7-8 | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:meshHeading | pubmed-meshheading:18064431... | lld:pubmed |
| pubmed-article:18064431 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18064431 | pubmed:articleTitle | Galectin-2 induces apoptosis of lamina propria T lymphocytes and ameliorates acute and chronic experimental colitis in mice. | lld:pubmed |
| pubmed-article:18064431 | pubmed:affiliation | Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charité-Universitätsmedizin, Berlin, Germany. | lld:pubmed |
| pubmed-article:18064431 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18064431 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:171134 | entrezgene:pubmed | pubmed-article:18064431 | lld:entrezgene |
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