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pubmed-article:18061185pubmed:abstractTextPathological fractures in patients with primary bone sarcomas should not be considered an absolute indication for amputation. Initial fracture management should include cast immobilisation or external fixation avoiding tumour-cell dissemination. The extent of fracture displacement and the type of fracture stabilisation may affect the outcome of patients with primary bone sarcomas presenting with pathological fractures. Patients with high-grade primary bone sarcomas should be treated by neo-adjuvant chemotherapy, and limb-salvage surgery. Pathological fractures in chemo-resistant primary bone sarcomas are a relative contraindication for limb salvage surgery.lld:pubmed
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pubmed-article:18061185pubmed:articleTitlePathological fractures in primary bone sarcomas.lld:pubmed
pubmed-article:18061185pubmed:affiliationFirst Department of Orthopaedics, Athens University Medical School, Athens, Greece. pjp@hol.grlld:pubmed
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