| pubmed-article:18060686 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C0040421 | lld:lifeskim |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:18060686 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:18060686 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:18060686 | pubmed:dateCreated | 2008-1-21 | lld:pubmed |
| pubmed-article:18060686 | pubmed:abstractText | To determine whether human papillomaviruses (HPV) positive tonsillar squamous cell carcinoma (SCC) represent a specific entity, we studied the prevalence of HPV association and of tobacco/alcohol exposure in a series of 52 cases of tonsillar SCC cases. p53, p16, and pRb levels, deregulated by viral oncoproteins were assessed. Forty patients reported tobacco/alcohol exposure, 10 reported no exposure. HPV DNA was found in 32/52 (62%) cases, (HPV16 genotype in 27). All patients with no history of tobacco-alcohol exposure presented HPV positive tumor (p=0.0008). A strong correlation was observed between positive HPV status, decrease in pRB and increase in p16 expression level. 5 year overall survival rate was higher in HPV16 positive patients than in HPV negative (71% versus 36%; p=0.023). HPV status remained a significant prognostic factor in multivariate analysis. Tonsillar SCC can thus be divided in HPV positive and negative subgroups with different oncogenesis and response to treatment. | lld:pubmed |
| pubmed-article:18060686 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18060686 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18060686 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18060686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18060686 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18060686 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18060686 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18060686 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:Sastre-GarauX... | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:RodriguezJosé... | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:FréneauxPaulP | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:JouffroyThoma... | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:ThiouxMartine... | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:CharfiLamiaL | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:GirodAngéliqu... | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:18060686 | pubmed:author | pubmed-author:PointDanielD | lld:pubmed |
| pubmed-article:18060686 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18060686 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:18060686 | pubmed:volume | 260 | lld:pubmed |
| pubmed-article:18060686 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18060686 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18060686 | pubmed:pagination | 72-8 | lld:pubmed |
| pubmed-article:18060686 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:18060686 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18060686 | pubmed:articleTitle | Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcome. | lld:pubmed |
| pubmed-article:18060686 | pubmed:affiliation | Department of Tumor Biology, Institut Curie 26 rue d'Ulm 75248 Paris Cedex 05, France. | lld:pubmed |
| pubmed-article:18060686 | pubmed:publicationType | Journal Article | lld:pubmed |
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