| pubmed-article:18055460 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:18055460 | lifeskim:mentions | umls-concept:C1709100 | lld:lifeskim |
| pubmed-article:18055460 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:18055460 | pubmed:dateCreated | 2008-2-11 | lld:pubmed |
| pubmed-article:18055460 | pubmed:abstractText | We show that co-expression of interleukin 15 (IL-15) and IL-15 receptor alpha (IL-15Ralpha) in the same cell allows for the intracellular interaction of the two proteins early after translation, resulting in increased stability and secretion of both molecules as a complex. In the absence of co-expressed IL-15Ralpha, a large portion of the produced IL-15 is rapidly degraded immediately after synthesis. Co-injection into mice of IL-15 and IL-15Ralpha expression plasmids led to significantly increased levels of the cytokine in serum as well as increased biological activity of IL-15. Examination of natural killer cells and T lymphocytes in mouse organs showed a great expansion of both cell types in the lung, liver, and spleen. The presence of IL-15Ralpha also increased the number of CD44(high) memory cells with effector phenotype (CD44(high)CD62L-). Thus, mutual stabilization of IL-15 and IL-15Ralpha leads to remarkable increases in production, stability, and tissue availability of bioactive IL-15 in vivo. The in vivo data show that the most potent form of IL-15 is as part of a complex with its receptor alpha either on the surface of the producing cells or as a soluble extracellular complex. These results explain the reason for coordinate expression of IL-15 and IL-15Ralpha in the same cell and suggest that the IL-15Ralpha is part of the active IL-15 cytokine rather than part of the receptor. | lld:pubmed |
| pubmed-article:18055460 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18055460 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18055460 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18055460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18055460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18055460 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18055460 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18055460 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:PavlakisGeorg... | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:FelberBarbara... | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:ValentinAnton... | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:RosatiMargher... | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:AliceaCandido... | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:KulkarniViraj... | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:JalahRashmiR | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:ZhangGen-MuGM | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:BergamaschiCr... | lld:pubmed |
| pubmed-article:18055460 | pubmed:author | pubmed-author:PatelVainavV | lld:pubmed |
| pubmed-article:18055460 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18055460 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:18055460 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:18055460 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18055460 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18055460 | pubmed:pagination | 4189-99 | lld:pubmed |
| pubmed-article:18055460 | pubmed:meshHeading | pubmed-meshheading:18055460... | lld:pubmed |
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| pubmed-article:18055460 | pubmed:meshHeading | pubmed-meshheading:18055460... | lld:pubmed |
| pubmed-article:18055460 | pubmed:meshHeading | pubmed-meshheading:18055460... | lld:pubmed |
| pubmed-article:18055460 | pubmed:meshHeading | pubmed-meshheading:18055460... | lld:pubmed |
| pubmed-article:18055460 | pubmed:meshHeading | pubmed-meshheading:18055460... | lld:pubmed |
| pubmed-article:18055460 | pubmed:meshHeading | pubmed-meshheading:18055460... | lld:pubmed |
| pubmed-article:18055460 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18055460 | pubmed:articleTitle | Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity. | lld:pubmed |
| pubmed-article:18055460 | pubmed:affiliation | Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, NCI-Frederick, National Instsitutes of Health, MD 21702-1201, USA. | lld:pubmed |
| pubmed-article:18055460 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18055460 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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