| pubmed-article:18054491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18054491 | lifeskim:mentions | umls-concept:C0206510 | lld:lifeskim |
| pubmed-article:18054491 | lifeskim:mentions | umls-concept:C0024728 | lld:lifeskim |
| pubmed-article:18054491 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18054491 | lifeskim:mentions | umls-concept:C0049901 | lld:lifeskim |
| pubmed-article:18054491 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:18054491 | pubmed:dateCreated | 2008-3-17 | lld:pubmed |
| pubmed-article:18054491 | pubmed:abstractText | Some Mannich bases of 7-hydroxycoumarin (2) and their simple derivatives (3 and 4) were prepared and tested against viruses containing single-stranded, positive-sense RNA genomes (ssRNA(+)). This study was directed toward Flaviviridae and, in particular, HCV surrogate viruses (BVDV, YFV). The 7-hydroxy derivatives 2 were generally devoid of activity, but when position 7 was propylated, the resulting 7-propyloxy derivatives 3 were in some cases endowed with an interesting activity against BVDV. The formation of 7-benzoyl derivatives 4 gave compounds generally lacking in activity against Flaviviridae, whereas the appearance of activity against RSV has been observed. Also some unsymmetrical methylene derivatives 5-7 (namely coumarins bridged to chromones or indoles) were found moderately active in antiviral tests. Derivatives 3 were submitted to a molecular modeling study using DNA polymerase of HCV as a target. The good correlation between calculated molecular modeling IC(50) and experimental EC(50) indicates that DNA polymerase is potentially involved in the inhibition of surrogate HCV viruses. | lld:pubmed |
| pubmed-article:18054491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18054491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054491 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18054491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18054491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18054491 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:18054491 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:LoddoRobertaR | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:La... | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:FermegliaMaur... | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:FerroneMarcoM | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:PriclSabrinaS | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:BalbiAlessand... | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:MazzeiMauroM | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:NiedduErikaE | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:IbbaCristinaC | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:MieleMariange... | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:MarongiuFabio... | lld:pubmed |
| pubmed-article:18054491 | pubmed:author | pubmed-author:MazzeiMarco... | lld:pubmed |
| pubmed-article:18054491 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18054491 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18054491 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:18054491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18054491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18054491 | pubmed:pagination | 2591-605 | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
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| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:meshHeading | pubmed-meshheading:18054491... | lld:pubmed |
| pubmed-article:18054491 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18054491 | pubmed:articleTitle | Activity of Mannich bases of 7-hydroxycoumarin against Flaviviridae. | lld:pubmed |
| pubmed-article:18054491 | pubmed:affiliation | Department of Pharmaceutical Sciences, Viale Benedetto XV, 3, 16132 Genova, Italy. | lld:pubmed |
| pubmed-article:18054491 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18054491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18054491 | lld:chembl |
