| pubmed-article:18046008 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C1176472 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C0019010 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C0205232 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C1552933 | lld:lifeskim |
| pubmed-article:18046008 | lifeskim:mentions | umls-concept:C2700485 | lld:lifeskim |
| pubmed-article:18046008 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18046008 | pubmed:dateCreated | 2008-2-14 | lld:pubmed |
| pubmed-article:18046008 | pubmed:abstractText | The spatial resolution of hemodynamic-based neuroimaging techniques, including functional magnetic resonance imaging, is limited by the degree to which neurons regulate their blood supply on a fine scale. Here we investigated the spatial detail of neurovascular events with a combination of high spatiotemporal resolution two-dimensional spectroscopic optical imaging, multichannel electrode recordings and cytochrome oxidase histology in the rodent whisker barrel field. After mechanical stimulation of a single whisker, we found two spatially distinct cortical hemodynamic responses: a transient response in the "upstream" branches of surface arteries and a later highly localized increase in blood volume centered on the activated cortical column. Although the spatial representation of this localized response exceeded that of a single "barrel," the spread of hemodynamic activity accurately reflected the neural response in neighboring columns rather than being due to a passive "overspill." These data confirm hemodynamics are capable of providing accurate "single-condition" maps of neural activity. | lld:pubmed |
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| pubmed-article:18046008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18046008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18046008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18046008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18046008 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18046008 | pubmed:issn | 0022-3077 | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:JonesMM | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:MartinCC | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:JohnstonDD | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:RedgravePP | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:MartindaleJJ | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:BerwickJJ | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:MayhewJ E WJE | lld:pubmed |
| pubmed-article:18046008 | pubmed:author | pubmed-author:KennerleyA... | lld:pubmed |
| pubmed-article:18046008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18046008 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:18046008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18046008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18046008 | pubmed:pagination | 787-98 | lld:pubmed |
| pubmed-article:18046008 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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