| pubmed-article:18042270 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C0680063 | lld:lifeskim |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C0039593 | lld:lifeskim |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C0684321 | lld:lifeskim |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C0750572 | lld:lifeskim |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C1527075 | lld:lifeskim |
| pubmed-article:18042270 | lifeskim:mentions | umls-concept:C0439792 | lld:lifeskim |
| pubmed-article:18042270 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:18042270 | pubmed:dateCreated | 2008-1-10 | lld:pubmed |
| pubmed-article:18042270 | pubmed:abstractText | The Regression of Offspring on Mid-Parent (ROMP) method is a test of association between a quantitative trait and a candidate locus. ROMP estimates the trait heritability and the heritability attributable to a locus and requires genotyping the offspring only. In this study, the theory underlying ROMP was revised (ROMP(rev)) and extended. Computer simulations were used to determine the type I error and power of the test of association, and the accuracy of the locus-specific heritability estimate. The ROMP(rev) test had good power at the 5% significance level with properly controlled type I error. Locus-specific heritability estimates were, on average, close to simulated values. For non-zero locus-specific heritability, the proposed standard error was downwardly biased, yielding reduced coverage of 95% confidence intervals. A bootstrap approach with proper coverage is suggested as a second step for loci of interest. ROMP(rev) was applied to a study of cardiovascular-related traits to illustrate its use. An association between polymorphisms within the fibrinogen gene cluster and plasma fibrinogen was detected (p < 0.005) that accounted for 29% of the estimated fibrinogen heritability. The ROMP(rev) method provides a computationally fast and simple way of testing for association and obtaining accurate estimates of locus-specific heritability while minimizing the genotyping required. | lld:pubmed |
| pubmed-article:18042270 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18042270 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18042270 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18042270 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18042270 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18042270 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18042270 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18042270 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18042270 | pubmed:issn | 0003-4800 | lld:pubmed |
| pubmed-article:18042270 | pubmed:author | pubmed-author:WilsonA FAF | lld:pubmed |
| pubmed-article:18042270 | pubmed:author | pubmed-author:JeeS HSH | lld:pubmed |
| pubmed-article:18042270 | pubmed:author | pubmed-author:BromanK WKW | lld:pubmed |
| pubmed-article:18042270 | pubmed:author | pubmed-author:MathiasR ARA | lld:pubmed |
| pubmed-article:18042270 | pubmed:author | pubmed-author:FallinM DMD | lld:pubmed |
| pubmed-article:18042270 | pubmed:author | pubmed-author:Roy-GagnonM-H... | lld:pubmed |
| pubmed-article:18042270 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18042270 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:18042270 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18042270 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18042270 | pubmed:pagination | 115-25 | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:meshHeading | pubmed-meshheading:18042270... | lld:pubmed |
| pubmed-article:18042270 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18042270 | pubmed:articleTitle | An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method. | lld:pubmed |
| pubmed-article:18042270 | pubmed:affiliation | Genometrics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, MD 21224, USA. | lld:pubmed |
| pubmed-article:18042270 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18042270 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:18042270 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:18042270 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
