| pubmed-article:18042267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18042267 | lifeskim:mentions | umls-concept:C0024305 | lld:lifeskim |
| pubmed-article:18042267 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:18042267 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18042267 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18042267 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:18042267 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:18042267 | pubmed:dateCreated | 2008-1-25 | lld:pubmed |
| pubmed-article:18042267 | pubmed:abstractText | Polymorphisms in the genes coding folate-metabolizing enzymes affect the risk of some forms of cancer. We investigated the association between these polymorphisms and non-Hodgkin lymphoma (NHL) risk in a population-based study (583 cases and 1700 controls). The MTHFR 677TT and CT genotypes were associated with reduced risk for NHL [odds ratios (OR) = 0.79; 95% confidence intervals (CI) = 0.65-0.98 for 677CT and 0.61; 0.45-0.82 for 677TT] and diffuse large B-cell lymphoma (DLBCL) (OR = 0.68; 0.51-0.88 for 677CT; OR = 0.56; 0.38-0.83 for 677TT). The MTHFR 1298CC genotype was associated with increased risk for NHL (OR = 1.71; 1.07-2.75) and T-cell lymphoma (OR = 3.05; 1.53-6.11). The MTRR 66GG genotype was associated with increased risk for DLBCL (OR = 1.56; 1.03-2.38) and the TYMS 2R2R genotype was associated with increased risk for T-cell lymphoma (OR = 2.83; 1.33-6.01). Using subjects with 3RG3RG as a reference group, TYMS 2R2R was associated with increased risk for T-cell lymphoma (OR = 2.46; 1.04-5.79). Interestingly, we observed a reduced association between the TYMS 2R3RG genotype and DLBCL (OR = 0.61; 0.38-0.99). These results suggest that MTHFR, MTRR and TYMS polymorphisms may play a significant role in the risk for NHL. | lld:pubmed |
| pubmed-article:18042267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18042267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18042267 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18042267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18042267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18042267 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18042267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18042267 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18042267 | pubmed:issn | 1365-2141 | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:KimHee NamHN | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:LeeJe-JungJJ | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:KimHyeoung-Jo... | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:KimYeo-Kyeoun... | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:ParkKyeong-So... | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:LeeIl-KwonIK | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:YangDeok-Hwan... | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:ShinMin-HoMH | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:ChoiJin-SuJS | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:ShinMyung-Geu... | lld:pubmed |
| pubmed-article:18042267 | pubmed:author | pubmed-author:TranHuong... | lld:pubmed |
| pubmed-article:18042267 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18042267 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:18042267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18042267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18042267 | pubmed:pagination | 287-94 | lld:pubmed |
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| pubmed-article:18042267 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18042267 | pubmed:articleTitle | Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma. | lld:pubmed |
| pubmed-article:18042267 | pubmed:affiliation | Genome Research Centre for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Jeollanamdo, Korea. | lld:pubmed |
| pubmed-article:18042267 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18042267 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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