Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:18041576rdf:typepubmed:Citationlld:pubmed
pubmed-article:18041576lifeskim:mentionsumls-concept:C0600388lld:lifeskim
pubmed-article:18041576lifeskim:mentionsumls-concept:C0035007lld:lifeskim
pubmed-article:18041576lifeskim:mentionsumls-concept:C1710082lld:lifeskim
pubmed-article:18041576lifeskim:mentionsumls-concept:C1704259lld:lifeskim
pubmed-article:18041576lifeskim:mentionsumls-concept:C1705987lld:lifeskim
pubmed-article:18041576lifeskim:mentionsumls-concept:C0678335lld:lifeskim
pubmed-article:18041576lifeskim:mentionsumls-concept:C1515926lld:lifeskim
pubmed-article:18041576pubmed:issue2lld:pubmed
pubmed-article:18041576pubmed:dateCreated2008-2-14lld:pubmed
pubmed-article:18041576pubmed:abstractTextDrug addiction, characterized by high rates of relapse, is recognized as a kind of neuroadaptive disorder. Since the extracellular signal-regulated kinase (ERK) pathway is critical to neuroplasticity in the adult brain, understanding the role this pathway plays is important for understanding the molecular mechanism underlying drug addiction and relapse. Here, we review previous literatures that focus on the effects of exposure to cocaine, amphetamine, Delta(9)-tetrahydrocannabinol (THC), nicotine, morphine, and alcohol on ERK signaling in the mesocorticolimbic dopamine system; these alterations of ERK signaling have been thought to contribute to the drug's rewarding effects and to the long-term maladaptation induced by drug abuse. We then discuss the possible upstreams of the ERK signaling pathway activated by exposure of drugs of abuse and the environmental cues previously paired with drugs. Finally, we argue that since ERK activation is a key molecular process in reinstatement of conditioned place preference and drug self-administration, the pharmacological manipulation of the ERK pathway is a potential treatment strategy for drug addiction.lld:pubmed
pubmed-article:18041576pubmed:languageenglld:pubmed
pubmed-article:18041576pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18041576pubmed:citationSubsetIMlld:pubmed
pubmed-article:18041576pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:18041576pubmed:statusMEDLINElld:pubmed
pubmed-article:18041576pubmed:monthFeblld:pubmed
pubmed-article:18041576pubmed:issn0272-4340lld:pubmed
pubmed-article:18041576pubmed:authorpubmed-author:JobEElld:pubmed
pubmed-article:18041576pubmed:authorpubmed-author:ZhaiHaifengHlld:pubmed
pubmed-article:18041576pubmed:authorpubmed-author:LiYanqinYlld:pubmed
pubmed-article:18041576pubmed:authorpubmed-author:WangXiXlld:pubmed
pubmed-article:18041576pubmed:issnTypePrintlld:pubmed
pubmed-article:18041576pubmed:volume28lld:pubmed
pubmed-article:18041576pubmed:ownerNLMlld:pubmed
pubmed-article:18041576pubmed:authorsCompleteYlld:pubmed
pubmed-article:18041576pubmed:pagination157-72lld:pubmed
pubmed-article:18041576pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:18041576pubmed:meshHeadingpubmed-meshheading:18041576...lld:pubmed
pubmed-article:18041576pubmed:meshHeadingpubmed-meshheading:18041576...lld:pubmed
pubmed-article:18041576pubmed:meshHeadingpubmed-meshheading:18041576...lld:pubmed
pubmed-article:18041576pubmed:meshHeadingpubmed-meshheading:18041576...lld:pubmed
pubmed-article:18041576pubmed:meshHeadingpubmed-meshheading:18041576...lld:pubmed
pubmed-article:18041576pubmed:meshHeadingpubmed-meshheading:18041576...lld:pubmed
pubmed-article:18041576pubmed:meshHeadingpubmed-meshheading:18041576...lld:pubmed
pubmed-article:18041576pubmed:year2008lld:pubmed
pubmed-article:18041576pubmed:articleTitleDrug-induced alterations in the extracellular signal-regulated kinase (ERK) signalling pathway: implications for reinforcement and reinstatement.lld:pubmed
pubmed-article:18041576pubmed:affiliationDepartment of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Hai Dian District, Beijing, 100083, China.lld:pubmed
pubmed-article:18041576pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18041576pubmed:publicationTypeReviewlld:pubmed
pubmed-article:18041576pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18041576lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18041576lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18041576lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18041576lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:18041576lld:pubmed