| pubmed-article:1804119 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1804119 | lifeskim:mentions | umls-concept:C0440744 | lld:lifeskim |
| pubmed-article:1804119 | lifeskim:mentions | umls-concept:C0012512 | lld:lifeskim |
| pubmed-article:1804119 | lifeskim:mentions | umls-concept:C0076726 | lld:lifeskim |
| pubmed-article:1804119 | lifeskim:mentions | umls-concept:C0016349 | lld:lifeskim |
| pubmed-article:1804119 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1804119 | pubmed:dateCreated | 1992-4-24 | lld:pubmed |
| pubmed-article:1804119 | pubmed:abstractText | Based on 4-methylcoumarinyl-7-amide (Amc) arginine and a series N-alkyloxycarbonyl derivatives of phenylalanine, eleven Amc-derivatives of the type ROCO-Phe-Arg-Amc (R = alkyl) were synthesized; also were n-C3H7OCO-Leu-Arg-Amc and n-C3H7OCO-D-Phe-Arg-Amc synthesized. The enzymatic hydrolysis of these compounds under the action of tissue and plasma human kallikreins were studied. Tissue kallikrein from human urine hydrolyzed the compounds with R = n-propyl and n-butyl and n-C3H7OCO-Leu-Arg-Amc more readily than the known substrates Z-Phe-Arg-Amc and H-Pro-Phe-Arg-Amc. n-C3H7OCO-D-Phe-Arg-Amc is a weak inhibitor of this enzyme (Ki = 1.5.10(-4) M). Human plasma kallikrein hydrolyzed these novel substrates at a lower rate than Z-Phe-Arg-Amc. | lld:pubmed |
| pubmed-article:1804119 | pubmed:language | rus | lld:pubmed |
| pubmed-article:1804119 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1804119 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1804119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1804119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1804119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1804119 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1804119 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1804119 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1804119 | pubmed:issn | 0132-3423 | lld:pubmed |
| pubmed-article:1804119 | pubmed:author | pubmed-author:RabinovichS... | lld:pubmed |
| pubmed-article:1804119 | pubmed:author | pubmed-author:PaskhinaT STS | lld:pubmed |
| pubmed-article:1804119 | pubmed:author | pubmed-author:PozdnevV FVF | lld:pubmed |
| pubmed-article:1804119 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1804119 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:1804119 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1804119 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1804119 | pubmed:pagination | 1352-6 | lld:pubmed |
| pubmed-article:1804119 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:meshHeading | pubmed-meshheading:1804119-... | lld:pubmed |
| pubmed-article:1804119 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1804119 | pubmed:articleTitle | [New dipeptide fluorogenic substrates of human tissue kallikrein]. | lld:pubmed |
| pubmed-article:1804119 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1804119 | pubmed:publicationType | English Abstract | lld:pubmed |
