| pubmed-article:18035491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18035491 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:18035491 | lifeskim:mentions | umls-concept:C0030958 | lld:lifeskim |
| pubmed-article:18035491 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:18035491 | lifeskim:mentions | umls-concept:C1418515 | lld:lifeskim |
| pubmed-article:18035491 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18035491 | pubmed:dateCreated | 2008-1-11 | lld:pubmed |
| pubmed-article:18035491 | pubmed:abstractText | Cerebral ischemia triggers inflammation and apoptosis, and the transcription factor NF-kappaB is a key regulator of both events. Here, we report on the induction of the peptidoglycan recognition protein-S (PGRP-S) in a mouse model of cerebral ischemia. Upregulation was reduced if the NF-kappaB subunit RelA was conditionally deleted in the brain. Regulation of PGRP-S transcription by RelA was confirmed in vitro. Cotransfection of a RelA expression plasmid stimulated the expression of a PGRP-S luciferase fusion gene. Mutation of two NF-kappaB response elements in the PGRP-S promoter disrupted stimulation by RelA. To investigate the function of PGRP-S in cerebral ischemia, we subjected PGRP-S(-/-) mice to cerebral ischemia. However, there was no difference in the infarct size in PGRP-S-deficient mice compared to controls. In summary, the data show that PGRP-S is induced in cerebral ischemia by RelA, but its role in ischemia is unclear. | lld:pubmed |
| pubmed-article:18035491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18035491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18035491 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18035491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18035491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18035491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18035491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18035491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18035491 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18035491 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:18035491 | pubmed:author | pubmed-author:LangMing-FeiM... | lld:pubmed |
| pubmed-article:18035491 | pubmed:author | pubmed-author:SchmidRolandR | lld:pubmed |
| pubmed-article:18035491 | pubmed:author | pubmed-author:SchwaningerMa... | lld:pubmed |
| pubmed-article:18035491 | pubmed:author | pubmed-author:SchneiderArmi... | lld:pubmed |
| pubmed-article:18035491 | pubmed:author | pubmed-author:DziarskiRoman... | lld:pubmed |
| pubmed-article:18035491 | pubmed:author | pubmed-author:KrügerCarolaC | lld:pubmed |
| pubmed-article:18035491 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18035491 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:18035491 | pubmed:volume | 430 | lld:pubmed |
| pubmed-article:18035491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18035491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18035491 | pubmed:pagination | 138-41 | lld:pubmed |
| pubmed-article:18035491 | pubmed:meshHeading | pubmed-meshheading:18035491... | lld:pubmed |
| pubmed-article:18035491 | pubmed:meshHeading | pubmed-meshheading:18035491... | lld:pubmed |
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| pubmed-article:18035491 | pubmed:meshHeading | pubmed-meshheading:18035491... | lld:pubmed |
| pubmed-article:18035491 | pubmed:meshHeading | pubmed-meshheading:18035491... | lld:pubmed |
| pubmed-article:18035491 | pubmed:meshHeading | pubmed-meshheading:18035491... | lld:pubmed |
| pubmed-article:18035491 | pubmed:meshHeading | pubmed-meshheading:18035491... | lld:pubmed |
| pubmed-article:18035491 | pubmed:meshHeading | pubmed-meshheading:18035491... | lld:pubmed |
| pubmed-article:18035491 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18035491 | pubmed:articleTitle | Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-kappaB. | lld:pubmed |
| pubmed-article:18035491 | pubmed:affiliation | Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. ming-fei.lang@pharma.uni-heidelberg.de | lld:pubmed |
| pubmed-article:18035491 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18035491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18035491 | lld:pubmed |
