| pubmed-article:18034776 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18034776 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:18034776 | lifeskim:mentions | umls-concept:C1185625 | lld:lifeskim |
| pubmed-article:18034776 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:18034776 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:18034776 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:18034776 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18034776 | pubmed:dateCreated | 2008-1-21 | lld:pubmed |
| pubmed-article:18034776 | pubmed:abstractText | Dendritic cells (DC) are crucial components of the early events of HIV infection. Dendritic cells capture and internalize HIV at mucosal surfaces and efficiently transfer the virus to CD4+ T cells in trans through infectious synapses (trans-infection pathway). Alternatively, HIV-1 replicates in DC (R5-HIV-1) (cis-infection pathway). Here, we analyzed HIV trafficking in DC during the trans-infection pathway as well as the cis-infection pathway. Confocal immunofluorescence microscopy demonstrated that after capture by DC, R5-HIV-1 and HIV-1 pseudotyped with vesicular stomatitis virus protein G colocalized in a viral compartment enriched in tetraspanins including CD81, CD82 and CD9, although at different levels, indicating a role of the viral envelope in targeting to the tetraspanin-rich compartment. Replication of R5-HIV-1 in DC (cis-infection pathway) also led to the accumulation, in an envelope-independent manner, of mature viral particles in a tetraspanin-rich compartment. A fraction of the HIV-1-containing compartments appeared directly accessible from the cell surface. In sharp contrast with the trans-infection pathway, the delta-subunit of the adaptor protein 3 (AP-3) complex was enriched on the HIV-1-containing compartment during R5-HIV-1 replication in DC (cis-infection pathway). Downregulation of AP-3 delta-adaptin reduced significantly viral particle release from HIV-1-infected DC. Together, these studies demonstrate a role for AP-3 in HIV replication in a tetraspanin-rich compartment in DC and contribute to the elucidation of the trafficking pathways required for DC-T cell transfer of HIV-1 infection, a critical step during the early events of HIV infection. | lld:pubmed |
| pubmed-article:18034776 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18034776 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18034776 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18034776 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18034776 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18034776 | pubmed:issn | 1398-9219 | lld:pubmed |
| pubmed-article:18034776 | pubmed:author | pubmed-author:PiguetVincent... | lld:pubmed |
| pubmed-article:18034776 | pubmed:author | pubmed-author:GarciaEduardo... | lld:pubmed |
| pubmed-article:18034776 | pubmed:author | pubmed-author:NikolicDamjan... | lld:pubmed |
| pubmed-article:18034776 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18034776 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:18034776 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18034776 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18034776 | pubmed:pagination | 200-14 | lld:pubmed |
| pubmed-article:18034776 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:18034776 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18034776 | pubmed:articleTitle | HIV-1 replication in dendritic cells occurs through a tetraspanin-containing compartment enriched in AP-3. | lld:pubmed |
| pubmed-article:18034776 | pubmed:affiliation | Department of Dermatology and Venereology, University Hospital and Medical School of Geneva, 1211 Geneva, Switzerland. | lld:pubmed |
| pubmed-article:18034776 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18034776 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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