| pubmed-article:18026094 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C0013936 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C0596803 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C0279266 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:18026094 | lifeskim:mentions | umls-concept:C1871460 | lld:lifeskim |
| pubmed-article:18026094 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18026094 | pubmed:dateCreated | 2007-12-17 | lld:pubmed |
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| pubmed-article:18026094 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18026094 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18026094 | pubmed:abstractText | Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have essential physiological roles in mature organisms. Here we describe the first known small-molecule inhibitor of BMP signaling-dorsomorphin, which we identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish. We found that dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Using dorsomorphin, we examined the role of BMP signaling in iron homeostasis. In vitro, dorsomorphin inhibited BMP-, hemojuvelin- and interleukin 6-stimulated expression of the systemic iron regulator hepcidin, which suggests that BMP receptors regulate hepcidin induction by all of these stimuli. In vivo, systemic challenge with iron rapidly induced SMAD1/5/8 phosphorylation and hepcidin expression in the liver, whereas treatment with dorsomorphin blocked SMAD1/5/8 phosphorylation, normalized hepcidin expression and increased serum iron levels. These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis. | lld:pubmed |
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| pubmed-article:18026094 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18026094 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18026094 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18026094 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18026094 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18026094 | pubmed:issn | 1552-4469 | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:DengDonna YDY | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:BlochKenneth... | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:Sachidanandan... | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:PetersonRanda... | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:LinHerbert... | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:BabittJodie... | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:YuPaul BPB | lld:pubmed |
| pubmed-article:18026094 | pubmed:author | pubmed-author:HongCharles... | lld:pubmed |
