| pubmed-article:18024112 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C0997249 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C2677316 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:18024112 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:18024112 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18024112 | pubmed:dateCreated | 2008-1-9 | lld:pubmed |
| pubmed-article:18024112 | pubmed:abstractText | This study was aimed to evaluate the apoptotic effects of thiosulfinates purified from Allium tuberosum L. on PC-3 human prostate cancer cells, and to elucidate detailed apoptosis mechanisms. Thiosulfinates significantly decrease viable cell numbers in dose- and time-dependent manners by apoptotic cell death via DNA fragmentation, chromatin condensation, and an increased sub-G1 phase. Apoptosis induced by thiosulfinates is associated with the activation of initiator caspase-8 and -9, and the effector caspase-3. In this study, thiosulfinates stimulated Bid cleavage, indicating that the apoptotic action of caspase-8-mediated Bid cleavage leads to the activation of caspase-9. Thiosulfinates decreased the expression of the anti-apoptotic protein Bcl-2 and increased the expression of the pro-apoptotic protein Bax. Thiosulfinates also increased the expression of AIF, a caspase-independent mitochondrial apoptosis factor, in PC-3 cells. These results indicate that thiosulfinates from A. tuberosum L. inhibit cell proliferation and induce apoptosis in PC-3 cells, which may be mediated via both caspase-dependent and -independent pathways. | lld:pubmed |
| pubmed-article:18024112 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18024112 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18024112 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18024112 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18024112 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:RhimJohng SJS | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:ParkJung-EunJ... | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:YamadaKojiK | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:KimSo-YeonSY | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:KimKee-HongKH | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:YeeSung-TaeST | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:ByunMyung-Woo... | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:ParkKyoung-Wu... | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:JeongIl-YunIY | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:SeoKwon-IlKI | lld:pubmed |
| pubmed-article:18024112 | pubmed:author | pubmed-author:KimJae-YongJY | lld:pubmed |
| pubmed-article:18024112 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18024112 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18024112 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:18024112 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18024112 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18024112 | pubmed:pagination | 199-204 | lld:pubmed |
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| pubmed-article:18024112 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18024112 | pubmed:articleTitle | Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells. | lld:pubmed |
| pubmed-article:18024112 | pubmed:affiliation | Department of Food and Nutrition, Sunchon National University, 315 Maegok, Suncheon, Jeonnam 540-742, Republic of Korea. | lld:pubmed |
| pubmed-article:18024112 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18024112 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:18024112 | lld:chembl |
