| pubmed-article:18022579 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0010825 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0009450 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C1709854 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0018133 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0009566 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0851807 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C1550587 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0445356 | lld:lifeskim |
| pubmed-article:18022579 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:18022579 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:18022579 | pubmed:dateCreated | 2007-11-20 | lld:pubmed |
| pubmed-article:18022579 | pubmed:abstractText | Serious infections are a major obstacle limiting the usefulness of unrelated donor marrow transplantation. Graft-versus-host disease (GVHD) and its therapy are associated with a high risk of opportunistic infection. In this study, patients were randomized to receive 1 of 2 GVHD prophylaxis strategies, marrow T cell depletion, and cyclosporine (TCD) or methotrexate/cyclosporine (M/C) after transplantation. The patients underwent transplantation between March 1995 and October 2000 as part of a multicenter randomized trial. As a secondary analysis, we analyzed infections in this study cohort. Among the 404 patients who underwent transplantation, a total of 1598 infections were reported. The rates of serious and fatal infections did not differ between the TCD and M/C groups. Bacterial infections accounted for 1/3 of serious infections in each treatment arm. A significantly higher incidence of severe cytomegalovirus (CMV) and life-threatening or fatal aspergillus infections was observed in the patients receiving TCD (CMV, 28% vs 17% [P = .02]; aspergillosis, 16% vs 7% [P < .01]). The only independent risk factor for serious infection was the development of grade III-IV acute GVHD (aGVHD; hazard ratio = 1.41; 95% confidence interval = 1.03-1.91). Strategies to speed immune recovery, even in the absence of GVHD, are needed to overcome the risk of infection after unrelated donor transplantation. | lld:pubmed |
| pubmed-article:18022579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18022579 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18022579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18022579 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18022579 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18022579 | pubmed:issn | 1083-8791 | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:WagnerJohn... | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:YanovichSaulS | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:KernanNancy... | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:HighKevin PKP | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:FreifeldAliso... | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:PapanicolaouG... | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:GodderKamar... | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:CarterShelly... | lld:pubmed |
| pubmed-article:18022579 | pubmed:author | pubmed-author:MendizabalAda... | lld:pubmed |
| pubmed-article:18022579 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18022579 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:18022579 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18022579 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18022579 | pubmed:pagination | 1487-98 | lld:pubmed |
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| pubmed-article:18022579 | pubmed:meshHeading | pubmed-meshheading:18022579... | lld:pubmed |
| pubmed-article:18022579 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:18022579 | pubmed:articleTitle | Higher risk of cytomegalovirus and aspergillus infections in recipients of T cell-depleted unrelated bone marrow: analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent graft-versus-host disease. | lld:pubmed |
| pubmed-article:18022579 | pubmed:affiliation | Department of Pediatrics and Medicine, University of Minnesota, Minneapolis, Minnesota, USA. vanbu004@umn.edu | lld:pubmed |
| pubmed-article:18022579 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18022579 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:18022579 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| pubmed-article:18022579 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18022579 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18022579 | lld:pubmed |
