| pubmed-article:18022315 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C0664123 | lld:lifeskim |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C1516044 | lld:lifeskim |
| pubmed-article:18022315 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:18022315 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:18022315 | pubmed:dateCreated | 2007-12-19 | lld:pubmed |
| pubmed-article:18022315 | pubmed:abstractText | Goal of this study was to investigate the pro-apoptotic properties of RRR-gamma-tocopherol (gammaT) in human breast cancer cells. gammaT was shown to induce cancer cells but not normal cells to undergo apoptosis, sensitize cancer cells to Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis, and increase death receptor 5 (DR5) mRNA, protein and cell surface expression. Knockdown of DR5 attenuated gammaT-induced apoptosis. Investigations of post-receptor signaling showed: caspase-8, Bid and Bax activation, increases in mitochondria permeability, cytochrome c release and caspase-9 activation. Thus, gammaT is a potent pro-apoptotic agent for human breast cancer cells inducing apoptosis via activation of DR5-mediated apoptotic pathway. | lld:pubmed |
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| pubmed-article:18022315 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18022315 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18022315 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18022315 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18022315 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:OsL OLO | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:LiJingJ | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:YuWeipingW | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:SandersBob... | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:KlineKimberly... | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:WangPeiP | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:Simmons-Mench... | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:ParkSook-Kyun... | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:TiwaryRichaR | lld:pubmed |
| pubmed-article:18022315 | pubmed:author | pubmed-author:ScottWenjun... | lld:pubmed |
| pubmed-article:18022315 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18022315 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:18022315 | pubmed:volume | 259 | lld:pubmed |
| pubmed-article:18022315 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18022315 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18022315 | pubmed:pagination | 165-76 | lld:pubmed |
| pubmed-article:18022315 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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