| pubmed-article:18007660 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18007660 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:18007660 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:18007660 | lifeskim:mentions | umls-concept:C0020963 | lld:lifeskim |
| pubmed-article:18007660 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18007660 | pubmed:dateCreated | 2007-12-17 | lld:pubmed |
| pubmed-article:18007660 | pubmed:abstractText | Cancer patients mount adaptive immune responses against their tumors. However, tumor develops many mechanisms to evade effective immunosurveillance. T-cell death caused by tumor plays a critical role in establishing tumor immunotolerance. Chronic stimulation of T cells by tumors leads to activation-induced cell death. Abortive stimulation of T cells by tolerogenic antigen-presenting cells loaded with tumor antigens leads to autonomous death of tumor-specific T cells. Therapeutic approaches that prevent T-cell death in the tumor microenvironment and tumor draining lymph nodes, therefore, should boost adaptive immune responses against cancer. | lld:pubmed |
| pubmed-article:18007660 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18007660 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18007660 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18007660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18007660 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18007660 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18007660 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18007660 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:18007660 | pubmed:author | pubmed-author:FinnO JOJ | lld:pubmed |
| pubmed-article:18007660 | pubmed:author | pubmed-author:LoHH | lld:pubmed |
| pubmed-article:18007660 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18007660 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:18007660 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18007660 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18007660 | pubmed:pagination | 70-9 | lld:pubmed |
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| pubmed-article:18007660 | pubmed:meshHeading | pubmed-meshheading:18007660... | lld:pubmed |
| pubmed-article:18007660 | pubmed:meshHeading | pubmed-meshheading:18007660... | lld:pubmed |
| pubmed-article:18007660 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18007660 | pubmed:articleTitle | T-cell death and cancer immune tolerance. | lld:pubmed |
| pubmed-article:18007660 | pubmed:affiliation | Department of Immunology, School of Medicine, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA. Binfeng@pitt.edu | lld:pubmed |
| pubmed-article:18007660 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18007660 | pubmed:publicationType | Review | lld:pubmed |
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