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pubmed-article:17998874pubmed:abstractTextFunctional leukocytes in blood transfusions can cause alloimmunization. Previous studies have shown that exposure of platelet concentrates to riboflavin and light (Mirasol PRT treatment) causes irreparable modification of nucleic acids. This treatment does not interfere with platelet function but does inhibit a wide range of immunological functions of leukocytes present in platelet concentrates. The current study evaluated the ability of Mirasol treatment to prevent alloimmunization by platelet transfusions in rats.lld:pubmed
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pubmed-article:17998874pubmed:articleTitleTreatment with riboflavin and ultraviolet light prevents alloimmunization to platelet transfusions and cardiac transplants.lld:pubmed
pubmed-article:17998874pubmed:affiliationDepartment of Pathology, John Hopkins Medical Institutions, Baltimore, MD 21205-2196, USA.lld:pubmed
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pubmed-article:17998874pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:17998874pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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