| pubmed-article:17998392 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17998392 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:17998392 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17998392 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:17998392 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:17998392 | lifeskim:mentions | umls-concept:C1690540 | lld:lifeskim |
| pubmed-article:17998392 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17998392 | pubmed:dateCreated | 2007-11-27 | lld:pubmed |
| pubmed-article:17998392 | pubmed:abstractText | We previously reported that joint swelling, synovial thickening, and cartilage matrix depletion induced by the injection of anti-collagen monoclonal antibodies and lipopolysaccharide (LPS) in BALB/c mice are increased in the absence of inhibitory leukocyte immunoglobulin (Ig)-like receptor B4 (LILRB4; formerly gp49B1) in a neutrophil-dependent manner. Because both mast cells and neutrophils express LILRB4, we sought a mast cell requirement with mast cell-deficient mouse strains, but unexpectedly obtained full arthritis in Kit(W-sh) mice and full resistance in Kit(W/KitW-v) mice. Kit(W-sh) mice were indeed mast cell deficient as assessed by histology and the absence of IgE/mast cell-dependent passive cutaneous anaphylaxis in the ear and joint as well as passive systemic anaphylaxis. Deletion of LILRB4 in Kit(W-sh) mice exacerbated anti-collagen/LPS-induced joint swelling that was abolished by neutrophil depletion, establishing a counterregulatory role for LILRB4 in the absence of mast cells. Whereas blood neutrophil levels and LPS-elicited tissue neutrophilia were equal in Kit(W-sh) and Kit+ mice, both were impaired in Kit(W/KitW-v) mice. Although both strains are mast cell deficient and protected from IgE-mediated anaphylactic reactions, their dramatically different responses to autoantibody-mediated, neutrophil-dependent immune complex arthritis suggest that other host differences determine the extent of mast cell involvement. Thus, a conclusion for an absolute mast cell role in a pathobiologic process requires evidence from both strains. | lld:pubmed |
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| pubmed-article:17998392 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17998392 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17998392 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17998392 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17998392 | pubmed:issn | 1540-9538 | lld:pubmed |
| pubmed-article:17998392 | pubmed:author | pubmed-author:FriendDaniel... | lld:pubmed |
| pubmed-article:17998392 | pubmed:author | pubmed-author:AustenK... | lld:pubmed |
| pubmed-article:17998392 | pubmed:author | pubmed-author:WeiXingX | lld:pubmed |
| pubmed-article:17998392 | pubmed:author | pubmed-author:KatzHoward... | lld:pubmed |
| pubmed-article:17998392 | pubmed:author | pubmed-author:ZhouJoseph... | lld:pubmed |
| pubmed-article:17998392 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17998392 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:17998392 | pubmed:volume | 204 | lld:pubmed |
| pubmed-article:17998392 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17998392 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17998392 | pubmed:pagination | 2797-802 | lld:pubmed |
| pubmed-article:17998392 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17998392 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17998392 | pubmed:articleTitle | Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. | lld:pubmed |
| pubmed-article:17998392 | pubmed:affiliation | Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:17998392 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17998392 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17998392 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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