Linked Life Data

17990318

Source:http://linkedlifedata.com/resource/pubmed/id/17990318

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pubmed-article:17990318pubmed:abstractTextIn human studies, low vitamin C intake has been associated with more severe Helicobacter pylori gastritis and a higher incidence of gastric cancer. However, vitamin C supplementation has not been definitively shown to protect against gastric cancer. Using vitamin C-deficient B6.129P2-Gulo(tm1Umc/mmcd) (gulo(-/-)) mice lacking L-gulono-gamma-lactone oxidase, we compared gastric lesions and Th1 immune responses in H. pylori-infected gulo(-/-) mice supplemented with low (33 mg/L) or high (3,300 mg/L) vitamin C in drinking water for 16 or 32 weeks. Vitamin C levels in plasma and gastric tissue correlated with the vitamin C supplementation levels in gulo(-/-) mice. H. pylori infection resulted in comparable gastritis and premalignant lesions in wildtype C57BL/6 and gulo(-/-) mice supplemented with high vitamin C, but lesions were less severe in gulo(-/-) mice supplemented with low vitamin C at 32 weeks post infection. The reduced gastric lesions in infected gulo(-/-) mice supplemented with low vitamin C correlated with reduced Th1-associated IgG2c, gastric IFN-gamma and TNF-alpha mRNA and higher H. pylori colonization levels. These results in the H. pylori-infected gulo(-/-) mouse model suggest that although supplementation with a high level of vitamin C achieved physiologically normal vitamin C levels in plasma and gastric tissue, this dose of vitamin C did not protect gulo(-/-) mice from H. pylori-induced premalignant gastric lesions. In addition, less severe gastric lesions in H.pylori infected gulo(-/-) mice supplemented with low vitamin C correlated with an attenuated Th1 inflammatory response.lld:pubmed
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pubmed-article:17990318pubmed:authorpubmed-author:WangXiang-Don...lld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:ChienKuo-Lion...lld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:WangTimothy...lld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:FoxJames GJGlld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:WharyMark TMTlld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:RogersArlin...lld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:LeeChung-WeiC...lld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:VarroAndreaAlld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:GeZhongmingZlld:pubmed
pubmed-article:17990318pubmed:authorpubmed-author:RickmanBarry...lld:pubmed
pubmed-article:17990318pubmed:copyrightInfo(c) 2007 Wiley-Liss, Inc.lld:pubmed
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