Linked Life Data

17984673

Source:http://linkedlifedata.com/resource/pubmed/id/17984673

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pubmed-article:17984673pubmed:abstractTextWe previously demonstrated that when the renin-angiotensin system (RAS) is transiently blocked by an angiotensin receptor blocker (ARB) in young spontaneously hypertensive rats (SHR), this results in a prolonged blood pressure decrease and protection against target organ damage. Aldosterone is an essential hormone in the RAS, and contributes to pathologic remodeling. Thus, part of the protective effects of the ARB may be due to inhibition of aldosterone-mediated effects. To test this hypothesis, in young SHR, we compared the effectiveness of transient treatment with the mineralocorticoid receptor blocker spironolactone with those obtained by the ARB losartan.lld:pubmed
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pubmed-article:17984673pubmed:year2007lld:pubmed
pubmed-article:17984673pubmed:articleTitleTransient prehypertensive treatment in spontaneously hypertensive rats: a comparison of spironolactone and losartan regarding long-term blood pressure and target organ damage.lld:pubmed
pubmed-article:17984673pubmed:affiliationDepartment of Pharmacology and Toxicology, University Maastricht, The Netherlands. marcus.baumann@lrz.tum.delld:pubmed
pubmed-article:17984673pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17984673pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:17984673pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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