| pubmed-article:17984071 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C1335858 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C0034786 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C0439780 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C1537421 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C2350440 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:17984071 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17984071 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17984071 | pubmed:dateCreated | 2008-1-18 | lld:pubmed |
| pubmed-article:17984071 | pubmed:abstractText | Previously, we found a novel gene, nuclear receptor interaction protein (NRIP), a transcription cofactor that can enhance an AR-driven PSA promoter activity in a ligand-dependent manner in prostate cancer cells. Here, we investigated NRIP regulation. We cloned a 413-bp fragment from the transcription initiation site of the NRIP gene that had strong promoter activity, was TATA-less and GC-rich, and, based on DNA sequences, contained one androgen response element (ARE) and three Sp1-binding sites (Sp1-1, Sp1-2, Sp1-3). Transient promoter luciferase assays, chromatin immunoprecipitation and small RNA interference analyses mapped ARE and Sp1-2-binding sites involved in NRIP promoter activation, implying that NRIP is a target gene for AR or Sp1. AR associates with the NRIP promoter through ARE and indirectly through Sp1-binding site via AR-Sp1 complex formation. Thus both ARE and Sp1-binding site within the NRIP promoter can respond to androgen induction. More intriguingly, NRIP plays a feed-forward role enhancing AR-driven NRIP promoter activity via NRIP forming a complex with AR to protect AR protein from proteasome degradation. This is the first demonstration that NRIP is a novel AR-target gene and that NRIP expression feeds forward and activates its own expression through AR protein stability. | lld:pubmed |
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| pubmed-article:17984071 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17984071 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17984071 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17984071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17984071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17984071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17984071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17984071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17984071 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17984071 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17984071 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17984071 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:17984071 | pubmed:author | pubmed-author:ChenShow-LiSL | lld:pubmed |
| pubmed-article:17984071 | pubmed:author | pubmed-author:TsaoYeou-Ping... | lld:pubmed |
| pubmed-article:17984071 | pubmed:author | pubmed-author:WangChih-Chia... | lld:pubmed |
| pubmed-article:17984071 | pubmed:author | pubmed-author:ChenPei-HongP... | lld:pubmed |
| pubmed-article:17984071 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17984071 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:17984071 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17984071 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17984071 | pubmed:pagination | 51-66 | lld:pubmed |
| pubmed-article:17984071 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:17984071 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17984071 | pubmed:articleTitle | Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability. | lld:pubmed |
| pubmed-article:17984071 | pubmed:affiliation | Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan. | lld:pubmed |
