| pubmed-article:17983596 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17983596 | lifeskim:mentions | umls-concept:C0018956 | lld:lifeskim |
| pubmed-article:17983596 | lifeskim:mentions | umls-concept:C1416498 | lld:lifeskim |
| pubmed-article:17983596 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:17983596 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17983596 | pubmed:dateCreated | 2007-11-21 | lld:pubmed |
| pubmed-article:17983596 | pubmed:abstractText | Among the subsets that define hematopoietic stem cells (HSCs), CD34- c-kit+ Sca-1+ lineage marker- (CD34-KSL) cells are regarded as one of the populations that have the highest enrichment of HSCs in adult mouse bone marrow. Here, we demonstrate that long-term repopulating hematopoietic stem cells (LTR-HSCs) have high expression of CD61 (integrin beta3) within the CD34-KSL population. Approximately 60% of CD34-KSL cells showed high expression of CD61. CD61HighCD34-KSL populations also exhibited significantly greater properties of HSC, such as expression of HSC markers, the side population (SP) phenotype, and ability for long-term repopulation. In both SP cells and non-SP (NSP) cells, CD61HighCD34-KSL cells also contained significantly more LTR-HSCs than CD61Low/-CD34-KSL cells. Our results indicate that CD61 is exploitable for HSC enrichment as a supportive positive cell surface marker. | lld:pubmed |
| pubmed-article:17983596 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17983596 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17983596 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17983596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17983596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17983596 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17983596 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17983596 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:OkanoTeruoT | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:YamatoMasayuk... | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:NishidaKohjiK | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:KobayashiYosh... | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:YangJosephJ | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:UmemotoTeruma... | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:ShiratsuchiYo... | lld:pubmed |
| pubmed-article:17983596 | pubmed:author | pubmed-author:TerasawaMasao... | lld:pubmed |
| pubmed-article:17983596 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17983596 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:17983596 | pubmed:volume | 365 | lld:pubmed |
| pubmed-article:17983596 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17983596 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17983596 | pubmed:pagination | 176-82 | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:meshHeading | pubmed-meshheading:17983596... | lld:pubmed |
| pubmed-article:17983596 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17983596 | pubmed:articleTitle | CD61 enriches long-term repopulating hematopoietic stem cells. | lld:pubmed |
| pubmed-article:17983596 | pubmed:affiliation | Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. | lld:pubmed |
| pubmed-article:17983596 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17983596 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16416 | entrezgene:pubmed | pubmed-article:17983596 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17983596 | lld:entrezgene |
