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pubmed-article:17983290pubmed:dateCreated2007-11-6lld:pubmed
pubmed-article:17983290pubmed:abstractTextTwenty-seven schizophrenia spectrum patients and 25 healthy controls performed a probabilistic version of the serial reaction time task (SRT) that included sequence trials embedded within random trials. Patients showed diminished, yet measurable, sequence learning. Postexperimental analyses revealed that a group of patients performed above chance when generating short spans of the sequence. This high-generation group showed SRT learning that was similar in magnitude to that of controls. Their learning was evident from the very 1st block; however, unlike controls, learning did not develop further with continued testing. A subset of 12 patients and 11 controls performed the SRT in conjunction with positron emission tomography. High-generation performance, which corresponded to SRT learning in patients, correlated to activity in the premotor cortex and parahippocampus. These areas have been associated with stimulus-driven visuospatial processing. Taken together, these results suggest that a subset of patients who showed moderate success on the SRT used an explicit stimulus-driven strategy to process the sequential stimuli. This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern.lld:pubmed
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pubmed-article:17983290pubmed:authorpubmed-author:AndreasenNanc...lld:pubmed
pubmed-article:17983290pubmed:authorpubmed-author:O'LearyDaniel...lld:pubmed
pubmed-article:17983290pubmed:authorpubmed-author:PontoLaura...lld:pubmed
pubmed-article:17983290pubmed:authorpubmed-author:JohnsonHans...lld:pubmed
pubmed-article:17983290pubmed:authorpubmed-author:TurnerBeth...lld:pubmed
pubmed-article:17983290pubmed:authorpubmed-author:MarvelCherie...lld:pubmed
pubmed-article:17983290pubmed:authorpubmed-author:PiersonRonald...lld:pubmed
pubmed-article:17983290pubmed:copyrightInfoPsycINFO Database Record (c) 2007 APA, all rights reserved.lld:pubmed
pubmed-article:17983290pubmed:issnTypePrintlld:pubmed
pubmed-article:17983290pubmed:volume21lld:pubmed
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