| pubmed-article:17977645 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C0927195 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C1515464 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C1515529 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C1520972 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C1517378 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C0439165 | lld:lifeskim |
| pubmed-article:17977645 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:17977645 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:17977645 | pubmed:dateCreated | 2007-11-20 | lld:pubmed |
| pubmed-article:17977645 | pubmed:abstractText | Interactions between neoplastic cells and neighboring stromal cells affect tumor morphology and behavior. The present study aimed to identify specific chromosomal aberrations that influence tumor-stroma interactions in colorectal cancer (CRC). Chromosome copy number changes of 23 carcinomas were analyzed by comparative genomic hybridization (array-CGH). Stroma percentage was determined by quantitative measurements of hematoxylin-eosin stained sections. Loss of 1p36 was associated with a decrease, and loss of 9q34 with an increase in CRC stroma percentage. Moreover, gain of 8q24 was associated with increased stroma percentage in CRCs with 20q gain, a major event in colon adenoma-to-carcinoma progression. These data indicate that different cancer genomes have different effects on tumor-stroma interactions, and suggest that determination of specific chromosomal aberrations in CRCs may be used as clinical parameter to predict tumor behavior. | lld:pubmed |
| pubmed-article:17977645 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17977645 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17977645 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17977645 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17977645 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17977645 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:17977645 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:17977645 | pubmed:author | pubmed-author:MongeraSandra... | lld:pubmed |
| pubmed-article:17977645 | pubmed:author | pubmed-author:PostmaCindyC | lld:pubmed |
| pubmed-article:17977645 | pubmed:author | pubmed-author:MeijerGerrit... | lld:pubmed |
| pubmed-article:17977645 | pubmed:author | pubmed-author:CarvalhoBeatr... | lld:pubmed |
| pubmed-article:17977645 | pubmed:author | pubmed-author:FijnemanRemon... | lld:pubmed |
| pubmed-article:17977645 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17977645 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:17977645 | pubmed:volume | 258 | lld:pubmed |
| pubmed-article:17977645 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17977645 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17977645 | pubmed:pagination | 223-9 | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:meshHeading | pubmed-meshheading:17977645... | lld:pubmed |
| pubmed-article:17977645 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17977645 | pubmed:articleTitle | Loss of 1p36, gain of 8q24, and loss of 9q34 are associated with stroma percentage of colorectal cancer. | lld:pubmed |
| pubmed-article:17977645 | pubmed:affiliation | Department of Medical Oncology, VU University Medical Center, CCA 2.60, P.O. Box 7057,1007MB Amsterdam, The Netherlands. RJA.Fijneman@vumc.nl | lld:pubmed |
| pubmed-article:17977645 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17977645 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17977645 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17977645 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17977645 | lld:pubmed |
