| pubmed-article:17976923 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17976923 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17976923 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:17976923 | lifeskim:mentions | umls-concept:C0679052 | lld:lifeskim |
| pubmed-article:17976923 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:17976923 | pubmed:issue | 8-10 | lld:pubmed |
| pubmed-article:17976923 | pubmed:dateCreated | 2007-11-16 | lld:pubmed |
| pubmed-article:17976923 | pubmed:abstractText | Ample research demonstrates that pathophysiological levels of the pro-inflammatory cytokine interleukin-1 (IL-1) produces detrimental effects on memory functioning. However, recent evidence suggests that IL-1 may be required for the normal physiological regulation of hippocampal-dependent memory. To substantiate the physiological role of IL-1 in learning and memory we examined the induction of IL-1 gene expression following a learning experience, and the effects of IL-1 signaling blockade, by either genetic or pharmacological manipulations, on memory functioning. We show that IL-1 gene expression is induced in the hippocampus 24h following fear-conditioning in wild type mice, but not in two mouse strains with impaired IL-1 signaling. Moreover, we report that mice with transgenic over-expression of IL-1 receptor antagonist restricted to the CNS (IL-1raTG) display impaired hippocampal-dependent and intact hippocampal-independent memory in the water maze and fear-conditioning paradigms. We further demonstrate that continuous administration of IL-1ra via osmotic minipumps during prenatal development disrupt memory performance in adult mice, suggesting that IL-1 plays a critical role not only in the formation of hippocampal-dependent memory but also in normal hippocampal development. Finally, we tested the dual role of IL-1 in memory by intracerebroventricular (ICV) administration of different doses of IL-1beta and IL-1ra following learning, providing the first systematic evidence that the involvement of IL-1 in hippocampal-dependent memory follows an inverted U-shaped pattern, i.e., a slight increase in brain IL-1 levels can improve memory, whereas any deviation from the physiological range, either by excess elevation in IL-1 levels or by blockade of IL-1 signaling, results in impaired memory. | lld:pubmed |
| pubmed-article:17976923 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17976923 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17976923 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17976923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17976923 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17976923 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17976923 | pubmed:issn | 0306-4530 | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:YirmiyaRazR | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:RenbaumPaulP | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:GoshenInbalI | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:Ben-HurTamirT | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:Levy-LahadEfr... | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:KreiselTirzah... | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:Ounallah-Saad... | lld:pubmed |
| pubmed-article:17976923 | pubmed:author | pubmed-author:ZalzsteinYael... | lld:pubmed |
| pubmed-article:17976923 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17976923 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:17976923 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17976923 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17976923 | pubmed:pagination | 1106-15 | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:meshHeading | pubmed-meshheading:17976923... | lld:pubmed |
| pubmed-article:17976923 | pubmed:articleTitle | A dual role for interleukin-1 in hippocampal-dependent memory processes. | lld:pubmed |
| pubmed-article:17976923 | pubmed:affiliation | Department of Psychology, The Hebrew University, Jerusalem 91905, Israel. | lld:pubmed |
| pubmed-article:17976923 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17976923 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16177 | entrezgene:pubmed | pubmed-article:17976923 | lld:entrezgene |
| entrez-gene:111343 | entrezgene:pubmed | pubmed-article:17976923 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17976923 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17976923 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17976923 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17976923 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17976923 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17976923 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17976923 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17976923 | lld:pubmed |
