| pubmed-article:1797449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C1512310 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:1797449 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:1797449 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:1797449 | pubmed:dateCreated | 1992-4-13 | lld:pubmed |
| pubmed-article:1797449 | pubmed:abstractText | 1. The effect of recombinant human interleukin-6 on the antiproliferation and differentiation inducing actions of all-trans retinoic acid in HL-60 human myeloid leukaemia cells was studied in short-term liquid suspension culture. 2. Interleukin-6 alone showed no significant effect on HL-60 human myeloid leukaemia cells. 3. The addition of interleukin-6 to all-trans retinoic acid-treated cultures of HL-60 human myeloid leukaemia cells significantly enhanced the desired antiproliferation effect of all-trans retinoic acid. 4. The combination of interleukin-6 with all-trans retinoic acid reduced the doses of all-trans retinoic acid required to induce the same differentiation of HL-60 cells as single agent by between 1.7- and 4.8-fold; that is, the efficacy of all-trans retinoic acid in inducing the differentiation of human myeloid leukaemia HL-60 cells was increased up to 4.8 times by its combination with interleukin-6. 5. The combination of all-trans retinoic acid and interleukin-6 could provide an effective alternative therapy for elderly myeloid leukaemia patients. | lld:pubmed |
| pubmed-article:1797449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1797449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1797449 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1797449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1797449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1797449 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1797449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1797449 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1797449 | pubmed:issn | 0305-1870 | lld:pubmed |
| pubmed-article:1797449 | pubmed:author | pubmed-author:HassanH THT | lld:pubmed |
| pubmed-article:1797449 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1797449 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:1797449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1797449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1797449 | pubmed:pagination | 847-51 | lld:pubmed |
| pubmed-article:1797449 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:meshHeading | pubmed-meshheading:1797449-... | lld:pubmed |
| pubmed-article:1797449 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1797449 | pubmed:articleTitle | Recombinant human interleukin-6 enhances the antiproliferation and differentiation inducing effects of retinoic acid in HL-60 human myeloid leukaemic cells. | lld:pubmed |
| pubmed-article:1797449 | pubmed:affiliation | Institut für Pharmazie, Freie Universität Berlin, Germany. | lld:pubmed |
| pubmed-article:1797449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1797449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
