| pubmed-article:17964153 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17964153 | lifeskim:mentions | umls-concept:C2610958 | lld:lifeskim |
| pubmed-article:17964153 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:17964153 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:17964153 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:17964153 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17964153 | pubmed:dateCreated | 2007-11-16 | lld:pubmed |
| pubmed-article:17964153 | pubmed:abstractText | Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1,2,3]thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure-activity relationship study revealed that small cyclic alkyl groups (i.e. cyclopropyl) and 2,6-dihalobenzylamides at the 4- and 5-positions of the [1,2,3]thiadiazole, respectively, were optimal. In addition, when a small alkyl group (i.e. methyl) was present on the benzylic position all the necroptosis inhibitory activity resided with the (S)-enantiomer. Finally, replacement of the [1,2,3]thiadiazole with a variety of thiophene derivatives was tolerated, although some erosion of potency was observed. | lld:pubmed |
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| pubmed-article:17964153 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17964153 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17964153 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17964153 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17964153 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17964153 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:17964153 | pubmed:author | pubmed-author:TuynJ WJW | lld:pubmed |
| pubmed-article:17964153 | pubmed:author | pubmed-author:CunyGregory... | lld:pubmed |
| pubmed-article:17964153 | pubmed:author | pubmed-author:PorcoJohn... | lld:pubmed |
| pubmed-article:17964153 | pubmed:author | pubmed-author:YuanJunyingJ | lld:pubmed |
| pubmed-article:17964153 | pubmed:author | pubmed-author:JeevanandamAr... | lld:pubmed |
| pubmed-article:17964153 | pubmed:author | pubmed-author:DegterevAlexe... | lld:pubmed |
| pubmed-article:17964153 | pubmed:author | pubmed-author:KeysHeatherH | lld:pubmed |
| pubmed-article:17964153 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17964153 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17964153 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17964153 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17964153 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17964153 | pubmed:pagination | 6836-40 | lld:pubmed |
| pubmed-article:17964153 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:meshHeading | pubmed-meshheading:17964153... | lld:pubmed |
| pubmed-article:17964153 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17964153 | pubmed:articleTitle | Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. | lld:pubmed |
| pubmed-article:17964153 | pubmed:affiliation | Laboratory for Drug Discovery in Neurodegeneration, Harvard Center for Neurodegeneration and Repair, Brigham & Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA. | lld:pubmed |
| pubmed-article:17964153 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17964153 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17964153 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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