| pubmed-article:17959795 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0016452 | lld:lifeskim |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0035020 | lld:lifeskim |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:17959795 | lifeskim:mentions | umls-concept:C0678335 | lld:lifeskim |
| pubmed-article:17959795 | pubmed:issue | 43 | lld:pubmed |
| pubmed-article:17959795 | pubmed:dateCreated | 2007-10-25 | lld:pubmed |
| pubmed-article:17959795 | pubmed:abstractText | A major problem in treating obesity is high rates of relapse to maladaptive food-taking habits during dieting. This relapse is often provoked by acute re-exposure to palatable food, food-associated cues, or stress. We used a reinstatement model, commonly used to study relapse to abused drugs, to explore the effect of peptide YY3-36 (PYY3-36) on reinstatement of high-fat (35%, 45 mg pellets) food seeking induced by acute exposure to the pellets (pellet priming), a cue previously associated with pellet delivery (pellet cue), or yohimbine (2 mg/kg, a pharmacological stressor). Rats were placed on a restricted diet (16 g of chow per day) and lever-pressed for the pellets for 9-12 sessions (6 h/d, every 48 h); pellet delivery was paired with a tone-light cue. They were then given 10-20 extinction sessions wherein lever presses were not reinforced with the pellets and subsequently tested for reinstatement of food seeking. Systemic PYY3-36 injections (100-200 microg/kg) decreased pellet priming- and pellet cue-induced reinstatement of food seeking but not yohimbine-induced reinstatement. Arcuate nucleus (Arc) injections of PYY3-36 (0.4 microg per side) decreased pellet priming-induced reinstatement. The attenuation of pellet priming-induced reinstatement by systemic PYY3-36 was reversed by systemic (2 mg/kg) but not Arc (0.5 microg per side) injections of the Y2 receptor antagonist BIIE0246. Arc PYY3-36 injections did not decrease pellet cue-induced reinstatement. Finally, systemic PYY3-36 injections had minimal effects on ongoing food self-administration or heroin priming- or heroin cue-induced reinstatement of heroin seeking. These data identify an effect of systemic PYY3-36 on relapse to food seeking that is independent of Y2 receptor activation in Arc and suggest that PYY3-36 should be considered for the treatment of relapse to maladaptive food-taking habits during dieting. | lld:pubmed |
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| pubmed-article:17959795 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17959795 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17959795 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
