| pubmed-article:17954973 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17954973 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:17954973 | lifeskim:mentions | umls-concept:C0023689 | lld:lifeskim |
| pubmed-article:17954973 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17954973 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17954973 | pubmed:dateCreated | 2007-10-23 | lld:pubmed |
| pubmed-article:17954973 | pubmed:abstractText | Beta-catenin is the key transducer of Wingless-type MMTV integration site family member (Wnt) signalling, upregulation of which is the cause of cancer of the colon and other tissues. In the absence of Wnt signals, beta-catenin is targeted to ubiquitin-proteasome-mediated degradation. Here we present the functional characterization of E3-ubiquitin ligase encoded by cul4B. RNAi-mediated knock-down of Cul4B in a mouse cell line C3H T10 (1/2) results in an increase in beta-catenin levels. Loss-of-function mutation in Drosophila cul4 also shows increased beta-catenin/Armadillo levels in developing embryos and displays a characteristic naked-cuticle phenotype. Immunoprecipitation experiments suggest that Cul4B and beta-catenin are part of a signal complex in Drosophila, mouse and human. These preliminary results suggest a conserved role for Cul4B in the regulation of beta-catenin levels. | lld:pubmed |
| pubmed-article:17954973 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17954973 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17954973 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17954973 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17954973 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17954973 | pubmed:issn | 0250-5991 | lld:pubmed |
| pubmed-article:17954973 | pubmed:author | pubmed-author:SrinivasUsha... | lld:pubmed |
| pubmed-article:17954973 | pubmed:author | pubmed-author:TripathiRacha... | lld:pubmed |
| pubmed-article:17954973 | pubmed:author | pubmed-author:KotaSatya... | lld:pubmed |
| pubmed-article:17954973 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17954973 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:17954973 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17954973 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17954973 | pubmed:pagination | 1133-8 | lld:pubmed |
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| pubmed-article:17954973 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17954973 | pubmed:articleTitle | Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin. | lld:pubmed |
| pubmed-article:17954973 | pubmed:affiliation | Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India. | lld:pubmed |
| pubmed-article:17954973 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17954973 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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