| pubmed-article:17951061 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C1413189 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C1611588 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C0053139 | lld:lifeskim |
| pubmed-article:17951061 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:17951061 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17951061 | pubmed:dateCreated | 2008-1-14 | lld:pubmed |
| pubmed-article:17951061 | pubmed:abstractText | A novel class of potent CCR3 receptor antagonists were designed and synthesized starting from N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide (1),which was found by subjecting our chemical library to high throughput screening (HTS). The CCR3 inhibitory activity of the synthesized compounds against eotaxin-induced Ca(2+) influx was evaluated using CCR3-expressing preB cells. Systematic chemical modifications of 1 revealed that the 6-fluoro-2-naphthylmethyl moiety was essential for CCR3 inhibitory activity in this new series of CCR3 antagonists. Further structural modifications of the benzamide and piperidine moieties of 1 led to the identification of exo-N-{8-[(6-fluoro-2-naphthyl)methyl]-8-azabicyclo[3.2.1]oct-3- yl}biphenyl-2-carboxamide [corrected] (31) as a potent CCR3 antagonist with an IC(50) value of 0.020 microM. | lld:pubmed |
| pubmed-article:17951061 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951061 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17951061 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951061 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17951061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951061 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17951061 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17951061 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17951061 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:TakeuchiMakot... | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:TsukamotoShin... | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:SuzukiKeikoK | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:MorokataTatsu... | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:OhtaMitsuakiM | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:KubotaHirokaz... | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:InamiHiroshiH | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:SatoIppeiI | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:HamadaNoritak... | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:MorihiraKoich... | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:IuraYosukeY | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:NittaAikoA | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:ImaokaTakayuk... | lld:pubmed |
| pubmed-article:17951061 | pubmed:author | pubmed-author:TakahashiTosh... | lld:pubmed |
| pubmed-article:17951061 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17951061 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17951061 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:17951061 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17951061 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17951061 | pubmed:pagination | 144-56 | lld:pubmed |
| pubmed-article:17951061 | pubmed:dateRevised | 2008-9-11 | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:meshHeading | pubmed-meshheading:17951061... | lld:pubmed |
| pubmed-article:17951061 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17951061 | pubmed:articleTitle | Synthesis and structure-activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists. | lld:pubmed |
| pubmed-article:17951061 | pubmed:affiliation | Drug Discovery Research, Astellas Pharma Inc., 21Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. ippei.sato@jp.astellas.com | lld:pubmed |
| pubmed-article:17951061 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17951061 | lld:chembl |
