| pubmed-article:17950601 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17950601 | lifeskim:mentions | umls-concept:C0376601 | lld:lifeskim |
| pubmed-article:17950601 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:17950601 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:17950601 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:17950601 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:17950601 | lifeskim:mentions | umls-concept:C0917728 | lld:lifeskim |
| pubmed-article:17950601 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:17950601 | pubmed:dateCreated | 2007-11-6 | lld:pubmed |
| pubmed-article:17950601 | pubmed:abstractText | The previously discovered salicylhydrazide class of compounds displayed potent HIV-1 integrase (IN) inhibitory activity. The development of this class of compounds as antiretroviral agents was halted due to cytotoxicity in the nanomolar to sub-micromolar range. We identified a novel class of non-cytotoxic hydrazide IN inhibitors utilizing the minimally required salicylhydrazide substructure as a template in a small-molecule database search. The novel hydrazides displayed low micromolar IN inhibitory activity and are several hundred-fold less cytotoxic than previously disclosed salicylhydrazide IN inhibitors. | lld:pubmed |
| pubmed-article:17950601 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17950601 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950601 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17950601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17950601 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17950601 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17950601 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:17950601 | pubmed:author | pubmed-author:NeamatiNouriN | lld:pubmed |
| pubmed-article:17950601 | pubmed:author | pubmed-author:WitvrouwMyria... | lld:pubmed |
| pubmed-article:17950601 | pubmed:author | pubmed-author:DebyserZegerZ | lld:pubmed |
| pubmed-article:17950601 | pubmed:author | pubmed-author:DayamRaveendr... | lld:pubmed |
| pubmed-article:17950601 | pubmed:author | pubmed-author:Al-MawsawiLai... | lld:pubmed |
| pubmed-article:17950601 | pubmed:author | pubmed-author:TaheriLalehL | lld:pubmed |
| pubmed-article:17950601 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17950601 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17950601 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:17950601 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17950601 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17950601 | pubmed:pagination | 6472-5 | lld:pubmed |
| pubmed-article:17950601 | pubmed:meshHeading | pubmed-meshheading:17950601... | lld:pubmed |
| pubmed-article:17950601 | pubmed:meshHeading | pubmed-meshheading:17950601... | lld:pubmed |
| pubmed-article:17950601 | pubmed:meshHeading | pubmed-meshheading:17950601... | lld:pubmed |
| pubmed-article:17950601 | pubmed:meshHeading | pubmed-meshheading:17950601... | lld:pubmed |
| pubmed-article:17950601 | pubmed:meshHeading | pubmed-meshheading:17950601... | lld:pubmed |
| pubmed-article:17950601 | pubmed:meshHeading | pubmed-meshheading:17950601... | lld:pubmed |
| pubmed-article:17950601 | pubmed:meshHeading | pubmed-meshheading:17950601... | lld:pubmed |
| pubmed-article:17950601 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17950601 | pubmed:articleTitle | Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors. | lld:pubmed |
| pubmed-article:17950601 | pubmed:affiliation | Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA. | lld:pubmed |
| pubmed-article:17950601 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17950601 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17950601 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17950601 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17950601 | lld:pubmed |
